Potential of MRI in Radiotherapy Mediated by Small Conjugates and Nanosystems

Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing health...

Full description

Saved in:
Bibliographic Details
Published in:Inorganics 2019-05, Vol.7 (5), p.59
Main Authors: Retna Putri Fauzia, Denkova, Antonia G, Djanashvili, Kristina
Format: Article
Language:English
Subjects:
Accelerators
Brain cancer
Chemical compounds
Computed tomography
Contrast agents
Contrast media
gadolinium
Image resolution
ionizing radiation
iron oxide nanoparticles
Kinases
Linear accelerators
Magnetic resonance imaging
Medical imaging
Morphology
Nanoparticles
Organs
Pharmacology
Physical sciences
Polyethylene glycol
Radiation dosage
Radiation therapy
Radiation tolerance
radiosensitization
relaxivity
theranostics
therapeutic radionuclides
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Radiation therapy has made tremendous progress in oncology over the last decades due to advances in engineering and physical sciences in combination with better biochemical, genetic and molecular understanding of this disease. Local delivery of optimal radiation dose to a tumor, while sparing healthy surrounding tissues, remains a great challenge, especially in the proximity of vital organs. Therefore, imaging plays a key role in tumor staging, accurate target volume delineation, assessment of individual radiation resistance and even personalized dose prescription. From this point of view, radiotherapy might be one of the few therapeutic modalities that relies entirely on high-resolution imaging. Magnetic resonance imaging (MRI) with its superior soft-tissue resolution is already used in radiotherapy treatment planning complementing conventional computed tomography (CT). Development of systems integrating MRI and linear accelerators opens possibilities for simultaneous imaging and therapy, which in turn, generates the need for imaging probes with therapeutic components. In this review, we discuss the role of MRI in both external and internal radiotherapy focusing on the most important examples of contrast agents with combined therapeutic potential.
ISSN:2304-6740
2304-6740
DOI:10.3390/inorganics7050059