Iron Status and Supplementation during Tuberculosis

Tuberculosis (TB) is characterised by chronic non-resolving inflammation. The effects of the host immune and inflammatory response to reduce iron acquisition by the bacteria, together with other contributing factors, predispose TB patients to anaemia of infection and iron deficiency anaemia (IDA). T...

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Bibliographic Details
Published in:Microorganisms (Basel) 2023-03, Vol.11 (3), p.785
Main Authors: Nienaber, Arista, Uyoga, Mary A, Dolman-Macleod, Robin C, Malan, Linda
Format: Article
Language:English
Subjects:
anaemia of infection
Anemia
Bacteria
Biomarkers
Clinical trials
Complications and side effects
Cytokines
Drug resistance
Enzymes
Granulomas
Hemoglobin
Infections
Inflammation
Inflammatory response
Iron
iron deficiency anaemia
Iron in the body
Malnutrition
Mortality
Nutrient deficiency
Patients
Physiological aspects
Proteins
Review
Risk factors
Supplements
Tuberculosis
Tumor necrosis factor-TNF
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Summary:Tuberculosis (TB) is characterised by chronic non-resolving inflammation. The effects of the host immune and inflammatory response to reduce iron acquisition by the bacteria, together with other contributing factors, predispose TB patients to anaemia of infection and iron deficiency anaemia (IDA). The presence of anaemia in TB patients has been linked to poor clinical outcomes. However, due to the reliance of the bacteria on iron, the management of anaemia in TB is complicated, and anaemia of infection is likely to resolve with correct TB drug treatment. On the other hand, IDA may require iron supplementation. This review aims to describe iron metabolism in TB and how this contributes to the development of iron deficiency and anaemia. Additionally, we summarise the evidence on the association between iron status and clinical outcomes as well as the available preclinical and clinical trials on iron supplementation in TB.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms11030785