Pathway of LCK Tyrosine Kinase and mTOR Signaling in Children with T-Cell Acute Lymphoblastic Leukemia

The aim of this study is to analyze available research on targeting signaling pathways for the development of new drugs in patients with T-cell acute lymphoblastic leukemia (T-ALL). This analysis focuses specifically on the role of LCK tyrosine kinase and mTOR signaling pathways in pediatric patient...

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Published in:Application of clinical genetics 2024-11, Vol.17, p.187-198
Main Authors: Rocka, Agata, Suchcicka, Maria, Jankowska, Aleksandra M, Woźniak, Magdalena M, Lejman, Monika
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Antimitotic agents
Antineoplastic agents
Children
Health aspects
pediatric
Pediatrics
Phenols
Review
signaling pathways
T cells
t-all
targeted therapy
Tyrosine
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container_title Application of clinical genetics
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creator Rocka, Agata
Suchcicka, Maria
Jankowska, Aleksandra M
Woźniak, Magdalena M
Lejman, Monika
description The aim of this study is to analyze available research on targeting signaling pathways for the development of new drugs in patients with T-cell acute lymphoblastic leukemia (T-ALL). This analysis focuses specifically on the role of LCK tyrosine kinase and mTOR signaling pathways in pediatric patients. Outcome: Current literature suggests that these pathways play a significant role in the regulation of T-cell cycles, making them potential therapeutic targets. However, despite promising findings, there remains a need for further research, particularly in pediatric populations, to fully understand the therapeutic implications and to optimize drug development. The conclusion drawn from this analysis highlights the significant influence of LCK and mTOR on T-cell cycle regulation, underscoring the importance of continued investigation in this area.
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source Taylor & Francis Open Access; Publicly Available Content Database; PubMed Central
subjects Acute lymphocytic leukemia
Antimitotic agents
Antineoplastic agents
Children
Health aspects
pediatric
Pediatrics
Phenols
Review
signaling pathways
T cells
t-all
targeted therapy
Tyrosine
title Pathway of LCK Tyrosine Kinase and mTOR Signaling in Children with T-Cell Acute Lymphoblastic Leukemia
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