Expression of P53, HER2 and Ki67 proteins in rats subjected to bladder augmentation with stomach, colon and ileum

PURPOSE: To study the expression of HER2, p53 and Ki67 proteins in cystoplasties. METHODS: Sixty rats were distributed randomly into three groups of 20 animals. Bladder augmentation was held to increase with ileum (Group I), colon (Group II) and stomach (Group III). Tissue samples of neobladder was...

Full description

Saved in:
Bibliographic Details
Published in:Acta cirúrgica brasileira 2016-01, Vol.31 (1), p.44-52
Main Authors: Miranda, Edinaldo Gonçalves de, Miranda, Celina Teresa Castelo Branco Couto de, Lopes, Antônio Igor Paraiba, Santana, Diógenes Miranda, Lemos Filho, João Emílio Pinheiro, Diniz, Thiago Pereira, Silva, José Figueredo, Waisberg, Jaques
Format: Article
Language:English
Subjects:
Genes, p53
Neoplasms
Rats
Urinary Bladder
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PURPOSE: To study the expression of HER2, p53 and Ki67 proteins in cystoplasties. METHODS: Sixty rats were distributed randomly into three groups of 20 animals. Bladder augmentation was held to increase with ileum (Group I), colon (Group II) and stomach (Group III). Tissue samples of neobladder was collected from each rat to its own control. The animals were sacrificed after 12 weeks. The neobladder was withdrawn for immunohistochemitry analysis of p53, HER2 and Ki67 expression. Wilcoxon and Mann-Whitney tests were used for statistical study. RESULTS: There were no significant changes in the expression of p53 and HER2 proteins. It was observed significant increase (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-865020160010000007