Analyses of Factors Associated with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Review

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is the exacerbation of a range of respiratory symptoms during the stable phase of chronic obstructive pulmonary disease (COPD). AECOPD is thus a dangerous stage and key event in the course of COPD, as its deterioration and frequen...

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Bibliographic Details
Published in:International journal of chronic obstructive pulmonary disease 2023-01, Vol.18, p.2707-2723
Main Authors: Qian, Yang, Cai, Chenting, Sun, Mengqing, Lv, Dan, Zhao, Yun
Format: Article
Language:English
Subjects:
acute exacerbation
Air pollution
Analysis
chronic obstructive pulmonary disease
Comorbidity
Development and progression
Immunoglobulin G
Infection
Lung diseases, Obstructive
Prevention
related risk factors
Review
Risk factors
Smoking
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Summary:Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is the exacerbation of a range of respiratory symptoms during the stable phase of chronic obstructive pulmonary disease (COPD). AECOPD is thus a dangerous stage and key event in the course of COPD, as its deterioration and frequency seriously affects the quality of life of patients and shortens their survival. Acute exacerbations occur and develop due to many factors such as infection, tobacco smoke inhalation, air pollution, comorbidities, airflow limitation, various biomarkers, history of previous deterioration, natural killer cell abnormalities, immunoglobulin G deficiency, genetics, abnormal muscle and nutritional status, negative psychology, and seasonal temperature changes. There is relatively limited research on the impact of the role of standardized management on the alleviation of AECOPD. However, with the establishment of relevant prevention and management systems and the promotion of artificial intelligence technology and Internet medical approaches, long-term effective and standardized management of COPD patients may help to achieve the quality of life and disease prognosis in COPD patients and reduce the risk of AE. Keywords: chronic obstructive pulmonary disease, acute exacerbation, related risk factors
ISSN:1178-2005
1176-9106
1178-2005
DOI:10.2147/COPD.S433183