Loading…

Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial

Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects...

Full description

Saved in:
Bibliographic Details
Published in:Current controlled trials in cardiovascular medicine 2024-01, Vol.25 (1), p.97-13, Article 97
Main Authors: Lai, Ming-Hui, Yu, Xiao-Ming, Lu, Yan, Wang, Hong-Lin, Fu, Wang, Zhou, Huan-Xia, Li, Yuan-Li, Hu, Jun, Xia, Jiayi, Hu, Zekai, Shan, Chun-Lei, Wang, Feng, Wang, Cong
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3
cites cdi_FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3
container_end_page 13
container_issue 1
container_start_page 97
container_title Current controlled trials in cardiovascular medicine
container_volume 25
creator Lai, Ming-Hui
Yu, Xiao-Ming
Lu, Yan
Wang, Hong-Lin
Fu, Wang
Zhou, Huan-Xia
Li, Yuan-Li
Hu, Jun
Xia, Jiayi
Hu, Zekai
Shan, Chun-Lei
Wang, Feng
Wang, Cong
description Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects are still unclear. Given the interconnected nature of motor learning within the brain network, we have proposed a novel approach known as multi-target tACS. This study aims to ascertain whether multi-target tACS is more effective than single-target stimulation in stroke patients and to further explore the potential underlying brain mechanisms by using techniques such as transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). This study employs a double-blind, sham-controlled, randomized controlled trial design with a 2-week intervention period. Both participants and outcome assessors will remain unaware of treatment allocation throughout the study. Thirty-nine stroke patients will be recruited and randomized into three distinct groups, including the sham tACS group (SS group), the single-target tACS group (ST group), and the multi-target tACS group (MT group), at a 1:1:1 ratio. The primary outcomes are series reaction time tests (SRTTs) combined with electroencephalograms (EEGs). The secondary outcomes include motor evoked potential (MEP), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), magnetic resonance imaging (MRI), Box and Block Test (BBT), and blood sample RNA sequencing. The tACS interventions for all three groups will be administered over a 2-week period, with outcome assessments conducted at baseline (T0) and 1 day (T1), 7 days (T2), and 14 days (T3) of the intervention phase. The study's findings will determine the potential of 40-Hz tACS to improve motor learning in stroke patients. Additionally, it will compare the effectiveness of multi-target and single-target approaches, shedding light on their respective improvement effects. Through the utilization of techniques such as TMS and MRI, the study aims to uncover the underlying brain mechanisms responsible for the therapeutic impact. Furthermore, the intervention has the potential to facilitate motor learning efficiency, thereby contributing to the advancement of future stroke rehabilitation treatment. Chinese Clinical Trial Registry ChiCTR2300073465. Registered on 11 July 2023.
doi_str_mv 10.1186/s13063-024-07913-4
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_6eba513b0ab74256b9def3a568453785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_6eba513b0ab74256b9def3a568453785</doaj_id><sourcerecordid>2921454979</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3</originalsourceid><addsrcrecordid>eNpdUstu1DAUjRCIlsIPsECW2JRFwO8kbKpqVKBSJRbA2nIce-rBsQfbqVS-jY_jzkypWjb21fV5XNunaV4T_J6QXn4ohGHJWkx5i7uBsJY_aY5Jx0UrKRFPH9RHzYtSNhhzNjD-vDliPR2IwPi4-XPhnDXV39hoS0E6TmjM2kc0W3Otoy8zSg7NS6i-rTqvbUU161gMLF4HpEO1Oerq4xqZJWcbKyrVAwF6KaLTer769g5BNaeaMgpW57gDg0WpOf20aAtIoJWP0FimW7TNgDQpIAd4jcBoSrP_bSdkUgRKCFDWDO4vm2dOh2Jf3e0nzY9PF99XX9qrr58vV-dXreFDV1uhreGjFmOHJyYEtbin2DDWj3oUWBjnpBRMDt3oOta7zmLGCcY97yWF3sROmsuD7pT0Rm2zn3W-VUl7tW-kvFY6V2-CVdKCEWEj1mPHqZDjMFnHtJA9F6zrBWidHbS2yzjbycDNsw6PRB-fRH-t1ulGEZhawqeBwumdQk6_Fluqmn0xNgQdbVqKogPFoqMS78ze_gfdpAW-K-xRhAt4nwFQ9IAyOZWSrbufhmC1S5o6JE1B0tQ-aYoD6c3De9xT_kWL_QX3R9N3</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2921454979</pqid></control><display><type>article</type><title>Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Lai, Ming-Hui ; Yu, Xiao-Ming ; Lu, Yan ; Wang, Hong-Lin ; Fu, Wang ; Zhou, Huan-Xia ; Li, Yuan-Li ; Hu, Jun ; Xia, Jiayi ; Hu, Zekai ; Shan, Chun-Lei ; Wang, Feng ; Wang, Cong</creator><creatorcontrib>Lai, Ming-Hui ; Yu, Xiao-Ming ; Lu, Yan ; Wang, Hong-Lin ; Fu, Wang ; Zhou, Huan-Xia ; Li, Yuan-Li ; Hu, Jun ; Xia, Jiayi ; Hu, Zekai ; Shan, Chun-Lei ; Wang, Feng ; Wang, Cong</creatorcontrib><description>Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects are still unclear. Given the interconnected nature of motor learning within the brain network, we have proposed a novel approach known as multi-target tACS. This study aims to ascertain whether multi-target tACS is more effective than single-target stimulation in stroke patients and to further explore the potential underlying brain mechanisms by using techniques such as transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). This study employs a double-blind, sham-controlled, randomized controlled trial design with a 2-week intervention period. Both participants and outcome assessors will remain unaware of treatment allocation throughout the study. Thirty-nine stroke patients will be recruited and randomized into three distinct groups, including the sham tACS group (SS group), the single-target tACS group (ST group), and the multi-target tACS group (MT group), at a 1:1:1 ratio. The primary outcomes are series reaction time tests (SRTTs) combined with electroencephalograms (EEGs). The secondary outcomes include motor evoked potential (MEP), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), magnetic resonance imaging (MRI), Box and Block Test (BBT), and blood sample RNA sequencing. The tACS interventions for all three groups will be administered over a 2-week period, with outcome assessments conducted at baseline (T0) and 1 day (T1), 7 days (T2), and 14 days (T3) of the intervention phase. The study's findings will determine the potential of 40-Hz tACS to improve motor learning in stroke patients. Additionally, it will compare the effectiveness of multi-target and single-target approaches, shedding light on their respective improvement effects. Through the utilization of techniques such as TMS and MRI, the study aims to uncover the underlying brain mechanisms responsible for the therapeutic impact. Furthermore, the intervention has the potential to facilitate motor learning efficiency, thereby contributing to the advancement of future stroke rehabilitation treatment. Chinese Clinical Trial Registry ChiCTR2300073465. Registered on 11 July 2023.</description><identifier>ISSN: 1745-6215</identifier><identifier>EISSN: 1745-6215</identifier><identifier>DOI: 10.1186/s13063-024-07913-4</identifier><identifier>PMID: 38291500</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>40-Hz multi-target stimulation ; Brain research ; Chinese medicine ; Clinical trials ; Cognition &amp; reasoning ; Cognitive ability ; Consent ; Electroencephalography ; Engineering research ; Magnetic resonance imaging ; Medical research ; Motor ability ; Motor learning ; Skills ; Stroke ; Stroke rehabilitation ; Study Protocol ; Transcranial alternating current stimulation ; Transcranial magnetic stimulation</subject><ispartof>Current controlled trials in cardiovascular medicine, 2024-01, Vol.25 (1), p.97-13, Article 97</ispartof><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3</citedby><cites>FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3</cites><orcidid>0000-0003-2289-2794</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826150/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826150/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38291500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lai, Ming-Hui</creatorcontrib><creatorcontrib>Yu, Xiao-Ming</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Wang, Hong-Lin</creatorcontrib><creatorcontrib>Fu, Wang</creatorcontrib><creatorcontrib>Zhou, Huan-Xia</creatorcontrib><creatorcontrib>Li, Yuan-Li</creatorcontrib><creatorcontrib>Hu, Jun</creatorcontrib><creatorcontrib>Xia, Jiayi</creatorcontrib><creatorcontrib>Hu, Zekai</creatorcontrib><creatorcontrib>Shan, Chun-Lei</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Wang, Cong</creatorcontrib><title>Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial</title><title>Current controlled trials in cardiovascular medicine</title><addtitle>Trials</addtitle><description>Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects are still unclear. Given the interconnected nature of motor learning within the brain network, we have proposed a novel approach known as multi-target tACS. This study aims to ascertain whether multi-target tACS is more effective than single-target stimulation in stroke patients and to further explore the potential underlying brain mechanisms by using techniques such as transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). This study employs a double-blind, sham-controlled, randomized controlled trial design with a 2-week intervention period. Both participants and outcome assessors will remain unaware of treatment allocation throughout the study. Thirty-nine stroke patients will be recruited and randomized into three distinct groups, including the sham tACS group (SS group), the single-target tACS group (ST group), and the multi-target tACS group (MT group), at a 1:1:1 ratio. The primary outcomes are series reaction time tests (SRTTs) combined with electroencephalograms (EEGs). The secondary outcomes include motor evoked potential (MEP), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), magnetic resonance imaging (MRI), Box and Block Test (BBT), and blood sample RNA sequencing. The tACS interventions for all three groups will be administered over a 2-week period, with outcome assessments conducted at baseline (T0) and 1 day (T1), 7 days (T2), and 14 days (T3) of the intervention phase. The study's findings will determine the potential of 40-Hz tACS to improve motor learning in stroke patients. Additionally, it will compare the effectiveness of multi-target and single-target approaches, shedding light on their respective improvement effects. Through the utilization of techniques such as TMS and MRI, the study aims to uncover the underlying brain mechanisms responsible for the therapeutic impact. Furthermore, the intervention has the potential to facilitate motor learning efficiency, thereby contributing to the advancement of future stroke rehabilitation treatment. Chinese Clinical Trial Registry ChiCTR2300073465. Registered on 11 July 2023.</description><subject>40-Hz multi-target stimulation</subject><subject>Brain research</subject><subject>Chinese medicine</subject><subject>Clinical trials</subject><subject>Cognition &amp; reasoning</subject><subject>Cognitive ability</subject><subject>Consent</subject><subject>Electroencephalography</subject><subject>Engineering research</subject><subject>Magnetic resonance imaging</subject><subject>Medical research</subject><subject>Motor ability</subject><subject>Motor learning</subject><subject>Skills</subject><subject>Stroke</subject><subject>Stroke rehabilitation</subject><subject>Study Protocol</subject><subject>Transcranial alternating current stimulation</subject><subject>Transcranial magnetic stimulation</subject><issn>1745-6215</issn><issn>1745-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdUstu1DAUjRCIlsIPsECW2JRFwO8kbKpqVKBSJRbA2nIce-rBsQfbqVS-jY_jzkypWjb21fV5XNunaV4T_J6QXn4ohGHJWkx5i7uBsJY_aY5Jx0UrKRFPH9RHzYtSNhhzNjD-vDliPR2IwPi4-XPhnDXV39hoS0E6TmjM2kc0W3Otoy8zSg7NS6i-rTqvbUU161gMLF4HpEO1Oerq4xqZJWcbKyrVAwF6KaLTer769g5BNaeaMgpW57gDg0WpOf20aAtIoJWP0FimW7TNgDQpIAd4jcBoSrP_bSdkUgRKCFDWDO4vm2dOh2Jf3e0nzY9PF99XX9qrr58vV-dXreFDV1uhreGjFmOHJyYEtbin2DDWj3oUWBjnpBRMDt3oOta7zmLGCcY97yWF3sROmsuD7pT0Rm2zn3W-VUl7tW-kvFY6V2-CVdKCEWEj1mPHqZDjMFnHtJA9F6zrBWidHbS2yzjbycDNsw6PRB-fRH-t1ulGEZhawqeBwumdQk6_Fluqmn0xNgQdbVqKogPFoqMS78ze_gfdpAW-K-xRhAt4nwFQ9IAyOZWSrbufhmC1S5o6JE1B0tQ-aYoD6c3De9xT_kWL_QX3R9N3</recordid><startdate>20240130</startdate><enddate>20240130</enddate><creator>Lai, Ming-Hui</creator><creator>Yu, Xiao-Ming</creator><creator>Lu, Yan</creator><creator>Wang, Hong-Lin</creator><creator>Fu, Wang</creator><creator>Zhou, Huan-Xia</creator><creator>Li, Yuan-Li</creator><creator>Hu, Jun</creator><creator>Xia, Jiayi</creator><creator>Hu, Zekai</creator><creator>Shan, Chun-Lei</creator><creator>Wang, Feng</creator><creator>Wang, Cong</creator><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-2289-2794</orcidid></search><sort><creationdate>20240130</creationdate><title>Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial</title><author>Lai, Ming-Hui ; Yu, Xiao-Ming ; Lu, Yan ; Wang, Hong-Lin ; Fu, Wang ; Zhou, Huan-Xia ; Li, Yuan-Li ; Hu, Jun ; Xia, Jiayi ; Hu, Zekai ; Shan, Chun-Lei ; Wang, Feng ; Wang, Cong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>40-Hz multi-target stimulation</topic><topic>Brain research</topic><topic>Chinese medicine</topic><topic>Clinical trials</topic><topic>Cognition &amp; reasoning</topic><topic>Cognitive ability</topic><topic>Consent</topic><topic>Electroencephalography</topic><topic>Engineering research</topic><topic>Magnetic resonance imaging</topic><topic>Medical research</topic><topic>Motor ability</topic><topic>Motor learning</topic><topic>Skills</topic><topic>Stroke</topic><topic>Stroke rehabilitation</topic><topic>Study Protocol</topic><topic>Transcranial alternating current stimulation</topic><topic>Transcranial magnetic stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Ming-Hui</creatorcontrib><creatorcontrib>Yu, Xiao-Ming</creatorcontrib><creatorcontrib>Lu, Yan</creatorcontrib><creatorcontrib>Wang, Hong-Lin</creatorcontrib><creatorcontrib>Fu, Wang</creatorcontrib><creatorcontrib>Zhou, Huan-Xia</creatorcontrib><creatorcontrib>Li, Yuan-Li</creatorcontrib><creatorcontrib>Hu, Jun</creatorcontrib><creatorcontrib>Xia, Jiayi</creatorcontrib><creatorcontrib>Hu, Zekai</creatorcontrib><creatorcontrib>Shan, Chun-Lei</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Wang, Cong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health &amp; Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Current controlled trials in cardiovascular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Ming-Hui</au><au>Yu, Xiao-Ming</au><au>Lu, Yan</au><au>Wang, Hong-Lin</au><au>Fu, Wang</au><au>Zhou, Huan-Xia</au><au>Li, Yuan-Li</au><au>Hu, Jun</au><au>Xia, Jiayi</au><au>Hu, Zekai</au><au>Shan, Chun-Lei</au><au>Wang, Feng</au><au>Wang, Cong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial</atitle><jtitle>Current controlled trials in cardiovascular medicine</jtitle><addtitle>Trials</addtitle><date>2024-01-30</date><risdate>2024</risdate><volume>25</volume><issue>1</issue><spage>97</spage><epage>13</epage><pages>97-13</pages><artnum>97</artnum><issn>1745-6215</issn><eissn>1745-6215</eissn><abstract>Transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects are still unclear. Given the interconnected nature of motor learning within the brain network, we have proposed a novel approach known as multi-target tACS. This study aims to ascertain whether multi-target tACS is more effective than single-target stimulation in stroke patients and to further explore the potential underlying brain mechanisms by using techniques such as transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). This study employs a double-blind, sham-controlled, randomized controlled trial design with a 2-week intervention period. Both participants and outcome assessors will remain unaware of treatment allocation throughout the study. Thirty-nine stroke patients will be recruited and randomized into three distinct groups, including the sham tACS group (SS group), the single-target tACS group (ST group), and the multi-target tACS group (MT group), at a 1:1:1 ratio. The primary outcomes are series reaction time tests (SRTTs) combined with electroencephalograms (EEGs). The secondary outcomes include motor evoked potential (MEP), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), magnetic resonance imaging (MRI), Box and Block Test (BBT), and blood sample RNA sequencing. The tACS interventions for all three groups will be administered over a 2-week period, with outcome assessments conducted at baseline (T0) and 1 day (T1), 7 days (T2), and 14 days (T3) of the intervention phase. The study's findings will determine the potential of 40-Hz tACS to improve motor learning in stroke patients. Additionally, it will compare the effectiveness of multi-target and single-target approaches, shedding light on their respective improvement effects. Through the utilization of techniques such as TMS and MRI, the study aims to uncover the underlying brain mechanisms responsible for the therapeutic impact. Furthermore, the intervention has the potential to facilitate motor learning efficiency, thereby contributing to the advancement of future stroke rehabilitation treatment. Chinese Clinical Trial Registry ChiCTR2300073465. Registered on 11 July 2023.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>38291500</pmid><doi>10.1186/s13063-024-07913-4</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2289-2794</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1745-6215
ispartof Current controlled trials in cardiovascular medicine, 2024-01, Vol.25 (1), p.97-13, Article 97
issn 1745-6215
1745-6215
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_6eba513b0ab74256b9def3a568453785
source Publicly Available Content Database; PubMed Central
subjects 40-Hz multi-target stimulation
Brain research
Chinese medicine
Clinical trials
Cognition & reasoning
Cognitive ability
Consent
Electroencephalography
Engineering research
Magnetic resonance imaging
Medical research
Motor ability
Motor learning
Skills
Stroke
Stroke rehabilitation
Study Protocol
Transcranial alternating current stimulation
Transcranial magnetic stimulation
title Effectiveness and brain mechanism of multi-target transcranial alternating current stimulation (tACS) on motor learning in stroke patients: study protocol for a randomized controlled trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A58%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effectiveness%20and%20brain%20mechanism%20of%20multi-target%20transcranial%20alternating%20current%20stimulation%20(tACS)%20on%20motor%20learning%20in%20stroke%20patients:%20study%20protocol%20for%20a%20randomized%20controlled%20trial&rft.jtitle=Current%20controlled%20trials%20in%20cardiovascular%20medicine&rft.au=Lai,%20Ming-Hui&rft.date=2024-01-30&rft.volume=25&rft.issue=1&rft.spage=97&rft.epage=13&rft.pages=97-13&rft.artnum=97&rft.issn=1745-6215&rft.eissn=1745-6215&rft_id=info:doi/10.1186/s13063-024-07913-4&rft_dat=%3Cproquest_doaj_%3E2921454979%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c497t-5aec4ba5b70d3552e0820c338bab505cff6653697bf738f7e034100848627bfd3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2921454979&rft_id=info:pmid/38291500&rfr_iscdi=true