Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors

Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from he...

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Published in:Communications biology 2024-05, Vol.7 (1), p.646-7, Article 646
Main Authors: Olofsson, Isa Amalie, Kristjansson, Ragnar P., Callesen, Ida, Davidsson, Olafur, Winsvold, Bendik, Hjalgrim, Henrik, Ostrowski, Sisse R., Erikstrup, Christian, Bruun, Mie Topholm, Pedersen, Ole Birger, Burgdorf, Kristoffer S., Banasik, Karina, Sørensen, Erik, Mikkelsen, Christina, Didriksen, Maria, Dinh, Khoa Manh, Mikkelsen, Susan, Brunak, Søren, Ullum, Henrik, Chalmer, Mona Ameri, Olesen, Jes, Kogelman, Lisette J. A., Hansen, Thomas Folkmann
Format: Article
Language:English
Subjects:
45/43
631/208/205/2138
692/617/375/226
Adult
Biomedical and Life Sciences
Blood & organ donations
Blood Donors
Cohort Studies
Denmark - epidemiology
Female
Genetic diversity
Genetic Loci
Genetic Predisposition to Disease
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Headache
Headache - genetics
Headaches
Humans
Life Sciences
Male
Middle Aged
Nervous system
Polymorphism, Single Nucleotide
RNA-Binding Proteins - genetics
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Summary:Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from headache, we performed a genome-wide association study of individuals who have never experienced a headache. We included 63,992 individuals (2,998 individuals with complete freedom from headache and 60,994 controls) from the Danish Blood Donor Study Genomic Cohort. Participants were included in two rounds, from 2015 to 2018 and in 2020. We discovered a genome-wide significant association, with the lead variant rs7904615[G] in ADARB2 (EAF = 27%, OR = 1.20 [1.13–1.27], p  = 3.92 × 10 −9 ). The genomic locus was replicated in a non-overlapping cohort of 13,032 individuals (539 individuals with complete freedom from headache and 12,493 controls) from the Danish Blood Donor Study Genomic Cohort ( p  
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-024-06299-y