Longitudinal cohort study highlights cancer-preventive benefits of lipid-lowering drugs

Cancer prevention is a serious global challenge. We aimed to investigate the relationship between lipid-lowering drugs and cancers. We included participants based on the UK Biobank. Lipid-lowering drug use was defined as new users before enrollment and the primary outcome was cancer incidence. The C...

Full description

Saved in:
Bibliographic Details
Published in:iScience 2024-09, Vol.27 (9), p.110680, Article 110680
Main Authors: Yuan, Zinuo, Ding, Chunhui, Duan, Jingjing, Lian, Ruonan, Shi, Yingzhou, Han, Junming, Dong, Hang, Song, Yongfeng, Zhao, Jiajun, Fan, Xiude
Format: Article
Language:English
Subjects:
Cancer
Human metabolism
Pharmacology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cancer prevention is a serious global challenge. We aimed to investigate the relationship between lipid-lowering drugs and cancers. We included participants based on the UK Biobank. Lipid-lowering drug use was defined as new users before enrollment and the primary outcome was cancer incidence. The Cox proportional hazards regression model was used to evaluate the association between drug use and outcome. We also performed a meta-analysis. We found that lipid-lowering drugs were associated with decreased risk of 21 types of cancers, including melanoma, skin cancer, and reproductive, hematological, urinary, digestive, nervous, and endocrine system cancers (all p 
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2024.110680