Implications of helplessness in depression: diagnosing mild cognitive impairment and analyzing its effects on cognitive decline in older adults

This study focuses on how elements of depression correlate with mild cognitive impairment (MCI) in older adults and the diagnostic efficacy of combining these components with the Mini-Mental State Examination (MMSE). The study also investigated the connection between individual depression components...

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Published in:Frontiers in aging neuroscience 2024-05, Vol.16, p.1378676-1378676
Main Authors: Lee, Boung Chul, Choe, Young Min, Suh, Guk-Hee, Keum, Musung, Kim, Shin Gyeom, Kim, Hyun Soo, Hwang, Jaeuk, Yi, Dahyun, Kim, Jee Wook
Format: Article
Language:English
Subjects:
Accuracy
Aging Neuroscience
Alcohol use
Alzheimer's disease
Body mass index
Cardiovascular disease
Cholesterol
Cognitive ability
cognitive decline
Dementia
depression
Exercise
helplessness
High density lipoprotein
Memory
Mental depression
mild cognitive impairment
Neurodegenerative diseases
Neuropsychology
Older people
Physical activity
Regression analysis
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Summary:This study focuses on how elements of depression correlate with mild cognitive impairment (MCI) in older adults and the diagnostic efficacy of combining these components with the Mini-Mental State Examination (MMSE). The study also investigated the connection between individual depression components and overall cognitive function, as measured by the total score (TS) of the consortium to establish a registry for Alzheimer's disease (AD) assessment battery. The study included 196 nondemented adults aged 65 to 90 years at a university hospital and community. Comprehensive clinical assessments including the 30-item Geriatric Depression Scale (GDS) to measure components of depressive symptoms, TS, and blood nutritional biomarkers. Our stepwise logistic regression analysis highlighted the 'helplessness item' (odds ratio = 4.531, 95% CI = 2.218 to 9.258,  
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2024.1378676