Cancer Risk Factors in Southern Brazil: Report of a Comprehensive, Matched Case-Control Study

To evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer syndrome...

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Published in:JCO global oncology 2023-09, Vol.9 (9), p.e2300006-e2300006
Main Authors: Giacomazzi, Juliana, Ziegelmann, Patricia Klarmann, da Costa, Samanta, Bittar, Camila Matzenbacher, Obst, Fernando Mariano, Rosset, Clévia, Macedo, Gabriel S, Bock, Hugo, Canal, Thais, Paese, Mari Ines, Benvenuti, Jean Lucas, Buj, Maria Carolina, Ashton-Prolla, Patricia, Goldim, José Roberto, Pozza, Roberta
Format: Article
Language:English
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Summary:To evaluate cancer risk factors among cancer cases and controls from Southern Brazil, to analyze a multigene hereditary panel testing (MGPT, 26 genes) for breast cancer (BC) and colorectal cancer (CCR) cases diagnosed age younger than 50 years and to characterize them for hereditary cancer syndrome (HCS) phenotypes. A case-control (matched by age group and sex) study was conducted on regional cancer. Data on exposure factors and first-/second-degree family history of cancer (1/2FHC) were collected. The MGPT was performed using Illumina next-generation sequencing technology. A total of 1,007 cases and 1,007 controls were included. The most frequent cancers were BC (n = 311), CCR (n = 147), prostate (n = 132), and lung cancers (n = 89). It was independently associated with cancer, 1/2FHC, tobacco consumption (TC), pesticide exposure (PE), solvent/glue exposure, and BMI
ISSN:2687-8941
2687-8941
DOI:10.1200/GO.23.00006