Exploring the biological behavior differences between retroperitoneal and non-retroperitoneal liposarcomas

Liposarcoma is a malignant tumor that originates from adipose tissue and can occur in any part of the body. There is currently no clear conclusion on whether there are significant differences in prognosis between liposarcoma at different anatomical locations, especially retroperitoneal liposarcoma (...

Full description

Saved in:
Bibliographic Details
Published in:Heliyon 2024-08, Vol.10 (15), p.e34878, Article e34878
Main Authors: Xi, Zhe, Zhuang, Aobo, Li, Xi, Ming, Turhong Maimaiti, Cheng, Yingxue, Zhang, Chenhe, Xie, Fuan, Wang, Yue, Yan, Guangting, Zheng, Jialiang, Lin, Zhenhang, Zhang, Geng, Li, Huichen, Wu, Ting, He, Qi, Li, Wengang
Format: Article
Language:English
Subjects:
adipose tissue
biomedical research
epidemiology
gene expression regulation
Japan
Liposarcoma
monitoring
neoplasms
Non-retroperitoneal
phenotype
prognosis
Retroperitoneal
SEER database
survival rate
transcriptome
Transcriptomics
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Liposarcoma is a malignant tumor that originates from adipose tissue and can occur in any part of the body. There is currently no clear conclusion on whether there are significant differences in prognosis between liposarcoma at different anatomical locations, especially retroperitoneal liposarcoma (RLPS) and non retroperitoneal liposarcoma (NRLPS). The aim of this study is to reveal whether there are differences in prognosis between these two locations of liposarcoma, and further explore the fundamental reasons behind these differences. We conducted an in-depth investigation into the factors affecting the prognosis of patients with liposarcoma by analyzing the data from the Surveillance, Epidemiology, and End Results Program (SEER) database. Then, we used propensity score matching (PSM) to balance these prognostic factors for comparative analysis of survival between RLPS and NRLPS. In addition, by analyzing transcriptome and whole exome data from TCGA and the Japan Genotypic Phenotype Archive (JGA), we identified genes with significant expression differences and explored changes in the immune microenvironment. Through analysis of RLPS and NRLPS patients in the SEER database, we observed significant prognostic differences between the two groups, with RLPS exhibiting worse prognosis (p 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e34878