Micronutrient status of individuals with overweight and obesity following 3 months' supplementation with PolyGlycopleX (PGX®) or psyllium: a randomized controlled trial

• Published in: BMC nutrition 2022-05, Vol.8 (1), p.42-42, Article 42
• Main Authors: Pal, Sebely, McKay, Jenny, Ho, Suleen, Jane, Monica, Gahler, Roland J, Wood, Simon
• Format: Article
• Language: English
• Subjects: Absorption; Body mass index; Clinical trials; Diet; Dietary fiber; Dietary fibre; Dietary minerals; Food; Metabolism; Micronutrients; Obesity; Overweight; PGX; Psyllium; Rice; Vegetarianism; Weight control
• ISSN: 2055-0928; 2055-0928
• DOI: 10.1186/s40795-022-00534-7

Safe and effective weight control strategies are needed to curtail the current obesity epidemic worldwide. Increasing dietary fibre has shown positive results with weight loss as well as in the reduction of metabolic syndrome risk factors. However, fibre can act as an inhibitor to the bioavailability of micronutrients in the gastrointestinal tract. While there is a substantial amount of scientific research into psyllium fibre, PolyGlycopleX (PGX®) is a novel fibre and as yet the effects of PGX® on micronutrient status is not well researched. To determine whether 3-months' supplementation with 15 g of psyllium or PGX® fibre daily affects micronutrient status of overweight and obese adults. Overweight and obese individuals with a BMI between 25-40 kg/m and aged between 18 and 65 years, but otherwise healthy, were instructed to consume a 5 g sachet of psyllium, PGX® fibre or a rice flour placebo three times a day for 52 weeks as part of a larger long-term study. Blood sample data for the first 3 months were analysed for associations between serum micronutrient levels and psyllium fibre and/or PGX® supplements. No significant differences between fibre supplement groups and micronutrient status were found after 3 months at p > 0.05. Dietary intake of vitamin C was significantly lower for PGX® at 3 months compared to baseline and compared to control (p