Paternal DNA methylation is remodeled to maternal levels in rice zygote

Epigenetic reprogramming occurs during reproduction to reset the genome for early development. In flowering plants, mechanistic details of parental methylation remodeling in zygote remain elusive. Here we analyze allele-specific DNA methylation in rice hybrid zygotes and during early embryo developm...

Full description

Saved in:
Bibliographic Details
Published in:Nature communications 2023-10, Vol.14 (1), p.6571-11, Article 6571
Main Authors: Liu, Qian, Ma, Xuan, Li, Xue, Zhang, Xinran, Zhou, Shaoli, Xiong, Lizhong, Zhao, Yu, Zhou, Dao-Xiu
Format: Article
Language:English
Subjects:
38/23
38/91
45/15
631/208/176/1988
631/449/2491/1559
Chromatin
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Embryogenesis
Embryonic Development - genetics
Embryonic growth stage
Embryos
Epigenetics
Fertilization
Flowering
Flowering plants
Gene expression
Genetic control
Genomes
Histones
Histones - genetics
Histones - metabolism
Humanities and Social Sciences
Hybrids
Life Sciences
multidisciplinary
Oryza - genetics
Oryza - metabolism
Plants (botany)
Rice
Science
Science (multidisciplinary)
Zygote - metabolism
Zygotes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Epigenetic reprogramming occurs during reproduction to reset the genome for early development. In flowering plants, mechanistic details of parental methylation remodeling in zygote remain elusive. Here we analyze allele-specific DNA methylation in rice hybrid zygotes and during early embryo development and show that paternal DNA methylation is predominantly remodeled to match maternal allelic levels upon fertilization, which persists after the first zygotic division. The DNA methylation remodeling pattern supports the predominantly maternal-biased gene expression during zygotic genome activation (ZGA) in rice. However, parental allelic-specific methylations are reestablished at the globular embryo stage and associate with allelic-specific histone modification patterns in hybrids. These results reveal that paternal DNA methylation is remodeled to match the maternal pattern during zygotic genome reprogramming and suggest existence of a chromatin memory allowing parental allelic-specific methylation to be maintained in the hybrid. Liu et al . show that zygotic remodelling of paternal DNA methylation is matched to maternal levels in hybrids and that parental-specific epigenomes are re-established during embryogenesis, highlighting genetic control of epigenetic inheritance.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-42394-0