The clinical significance of microvascular invasion in the surgical planning and postoperative sequential treatment in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common and most lethal malignant tumors in the world. Microvascular invasion (MVI) is a major risk factor for survival outcomes and intrahepatic metastasis after resection in patients with HCC. Relevant English literatures retrieved using PubMed on t...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.2415-10, Article 2415
Main Authors: Wang, Wentao, Guo, Yaxun, Zhong, Jingtao, Wang, Qi, Wang, Xin, Wei, Honglong, Li, Jie, Xiu, Peng
Format: Article
Language:English
Subjects:
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631/67
Biopsy
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Clinical significance
Combined Modality Therapy
Disease Management
Hepatectomy - adverse effects
Hepatectomy - methods
Hepatocellular carcinoma
Humanities and Social Sciences
Humans
Liver cancer
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Metastases
Microvasculature
Microvessels - pathology
multidisciplinary
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Patient Care Planning
Patients
Postoperative Complications
Risk Factors
Science
Science (multidisciplinary)
Survival
Treatment Outcome
Tumor Burden
Tumors
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Summary:Hepatocellular carcinoma (HCC) is one of the most common and most lethal malignant tumors in the world. Microvascular invasion (MVI) is a major risk factor for survival outcomes and intrahepatic metastasis after resection in patients with HCC. Relevant English literatures retrieved using PubMed on the research progress of MVI in patients with HCC were reviewed. For HCC patients, especially those with MVI, it is very important to develop a comprehensive and sequential treatment plan to support the long-term survival of patients. This manuscript reviewed and analyzed the risk factors for MVI; the preoperative prediction of MVI, which informs the selection of surgical strategies; and the current situation and future direction of comprehensive postoperative treatment strategies; to provide a basis for the comprehensive treatment of HCC patients with MVI. For HCC patients with MVI, the preoperative prediction of MVI may play a certain guiding role in planning procedures, and the comprehensive sequential postoperative pathological detection of HCC MVI may provide a basis for treatment decisions.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-82058-x