High Prevalence of Low Skeletal Muscle Mass Associated with Male Gender in Midlife and Older HIV-Infected Persons Despite CD4 Cell Reconstitution and Viral Suppression

Therapeutic goals for HIV-infected patients receiving antiretroviral therapy include minimizing risk of future physical disability. Presarcopenia and sarcopenia precede age-associated physical disability. We investigated their prevalence and the predictive value of patient mid-upper arm circumferenc...

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Bibliographic Details
Published in:Journal of the International Association of Providers of AIDS Care 2014-03, Vol.13 (2), p.145-152
Main Authors: Wasserman, Peter, Segal-Maurer, Sorana, Rubin, David S.
Format: Article
Language:English
Subjects:
Aged
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Antiretroviral therapy
Arm - anatomy & histology
Body Mass Index
Body Size
Body weight
CD4 Lymphocyte Count
Cross-Sectional Studies
Drug abuse
Female
Hand Strength
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - immunology
Human immunodeficiency virus
Humans
Indexes
Intravenous drugs
Male
Males
Middle age
Middle Aged
Muscle Strength Dynamometer
Muscle Weakness - epidemiology
Muscle, Skeletal
Muscular Atrophy - epidemiology
Musculoskeletal system
Odds Ratio
Patients
Physical disabilities
Predictions
Prevalence
Risk Factors
Sarcopenia
Sarcopenia - epidemiology
Sex Factors
Sex ratio
Substance abuse
Substance-Related Disorders - epidemiology
Viral Load
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Summary:Therapeutic goals for HIV-infected patients receiving antiretroviral therapy include minimizing risk of future physical disability. Presarcopenia and sarcopenia precede age-associated physical disability. We investigated their prevalence and the predictive value of patient mid-upper arm circumference (MUAC) for them. Eighty community-dwelling patients ≥45 years old demonstrating durable viral suppression were evaluated. Sarcopenia was defined as low skeletal muscle index (SMI, skeletal muscle kg/height m2) and either low strength or poor performance by handgrip dynamometry and gait speed, respectively. Presarcopenia was defined as low SMI only. MUAC was interpreted according to National Health Statistics percentile. Prevalence of sarcopenia and presarcopenia was 5.0% and 20.0%, respectively. Male gender (odds ratio [OR] 10.72; P < .026), recreational psychoactive substance use (OR 5.13; P < .037), and intravenous drug use transmission category (OR 6.94; P
ISSN:2325-9574
2325-9582
2325-9582
DOI:10.1177/2325957413495919