Diterpenoids from Plectranthus spp. as Potential Chemotherapeutic Agents via Apoptosis

Plectranthus spp. is widely known for its medicinal properties and bioactive metabolites. The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7α-Acetoxy-6β-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7β,6β-dihydroxyroyleanone6 (Diroy), and Parvifloron D (Parv)...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2020-06, Vol.13 (6), p.123
Main Authors: Śliwiński, Tomasz, Sitarek, Przemysław, Skała, Ewa, M. S. Isca, Vera, Synowiec, Ewelina, Kowalczyk, Tomasz, Bijak, Michał, Rijo, Patrícia
Format: Article
Language:English
Subjects:
apoptosis
Biological activity
Breast cancer
Cancer therapies
cytotoxic activity
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA damage
Gene expression
Leukemia
Lung cancer
Melanoma
Metabolites
Mitochondrial DNA
mitochondrial membrane potential
Plectranthus sp
ROS levels
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Summary:Plectranthus spp. is widely known for its medicinal properties and bioactive metabolites. The cytotoxic and genotoxic properties of the four known abietane diterpenoids: 7α-Acetoxy-6β-hydroxyroyleanone (Roy), 6,7-dehydroroyleanone (Deroy), 7β,6β-dihydroxyroyleanone6 (Diroy), and Parvifloron D (Parv), isolated from P. madagascariensis (Roy, DeRoy, and Diroy) and P. ecklonii (Parv) were evaluated. The tested compounds showed cytotoxic effects against the human leukemia cell line CCRF-CEM and the lung adenocarcinoma cell line A549. All tested compounds induced apoptosis by altering the level of pro- and anti-apoptotic genes. The results show that from the tested diterpenoids, Roy and Parv demonstrated the strongest activity in both human cancer cell lines, changing the permeability mitochondrial membrane potential and reactive oxygen species (ROS) levels, and possibly inducing mtDNA or nDNA damage. In conclusion, the abietane diterpenoids tested may be used in the future as potential natural chemotherapeutic agents
ISSN:1424-8247
1424-8247
DOI:10.3390/ph13060123