Multi-modal retinal scanning to measure retinal thickness and peripheral blood vessels in multiple sclerosis

Our purpose was to investigate changes to the retina in multiple sclerosis (MS) using established and novel modes of retinal image acquisition and analysis. 72 participants with MS and 80 healthy volunteers underwent retinal scanning with optical coherence tomography (OCT) and ultra-widefield (UWF)...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.20472-20472, Article 20472
Main Authors: Pearson, Thomas, Chen, Yingdi, Dhillon, Baljean, Chandran, Siddharthan, van Hemert, Jano, MacGillivray, Tom
Format: Article
Language:English
Subjects:
631/1647/245/2226
631/378/1341
631/378/1689/1666
692/53/2421
692/53/2423
692/699/375/1666
Blood vessels
Humanities and Social Sciences
Humans
Image processing
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Ophthalmoscopy
Peripheral blood
Retina
Retina - diagnostic imaging
Science
Science (multidisciplinary)
Thinning
Tomography, Optical Coherence
Veins
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Summary:Our purpose was to investigate changes to the retina in multiple sclerosis (MS) using established and novel modes of retinal image acquisition and analysis. 72 participants with MS and 80 healthy volunteers underwent retinal scanning with optical coherence tomography (OCT) and ultra-widefield (UWF) scanning laser ophthalmoscopy (SLO), over a two-year period. Changes in retinal nerve fibre layer (RNFL) thickness, macular volume and retinal blood vessel diameter were measured and parameters were then tested for associations with MS. Measurements from OCT showed that individuals with MS had a thinner RNFL and reduced macular volume when compared to healthy volunteers. On UWF images, participants with MS had reduced arterial widths in the inferior nasal quadrant of both eyes and reduced venous widths in the inferior nasal quadrant of right eyes. Longitudinal analysis showed that participants with MS had an accelerated annual rate of RNFL thinning in several regions of the retina. In conclusion, the assessment of OCT showed thinning of the RNFL and macula in concordance with previous reports on MS, while analysis of blood vessels in the retinal periphery from UWF-SLO images revealed novel changes.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24312-4