Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service - Health screening 11-year follow-up study

A comprehensive health index is needed to measure an individual's overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biolog...

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Bibliographic Details
Published in:Clinical interventions in aging 2018-01, Vol.13, p.429-436
Main Authors: Kang, Young Gon, Suh, Eunkyung, Lee, Jae-Woo, Kim, Dong Wook, Cho, Kyung Hee, Bae, Chul-Young
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aging
Aging - physiology
Analysis
Biological age
Biomarkers
Blood pressure
Cardiovascular disease
Cholesterol
Comprehensive index
Databases, Factual
Death
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Female
Financial services
Follow-Up Studies
Geriatric Assessment
Health
Health insurance
Health promotion
Health screening
Health Status
Health Status Indicators
Heart diseases
Hospitals
Humans
Hypertension
Koreans
Male
Medical examination
Medical screening
Medicine
Middle Aged
Mortality
National health insurance
Neoplasms - epidemiology
Older people
Original Research
Physiology
Population
Prognosis
Proportional Hazards Models
Republic of Korea
Risk Factors
Stroke
Stroke - epidemiology
Urine
Validity
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Summary:A comprehensive health index is needed to measure an individual's overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biological age (BA) in relation to all-cause mortality and age-related disease incidence based on National Sample Cohort database. This study was based on National Sample Cohort database of the National Health Insurance Service - Eligibility database and the National Health Insurance Service - Medical and Health Examination database of the year 2002 through 2013. BA model was developed based on the National Health Insurance Service - National Sample Cohort (NHIS - NSC) database and Cox proportional hazard analysis was done for mortality and major age-related disease incidence. For every 1 year increase of the calculated BA and chronological age difference, the hazard ratio for mortality significantly increased by 1.6% (1.5% in men and 2.0% in women) and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (
ISSN:1178-1998
1176-9092
1178-1998
DOI:10.2147/CIA.S157014