Therapeutic potential and mechanisms of stem cells in major depressive disorder: a comprehensive review

Depression is a common affective disorder characterized by persistent low mood, diminished interest or pleasure in normally enjoyable activities, disturbances in sleep patterns, and suicidal ideation. Conventional treatments often yield unsatisfactory results and are associated with several adverse...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-11, Vol.15, p.1476558
Main Authors: Li, Jiaqi, Wang, Yuqian, Zhang, Yucheng, Liu, Mengran, Rong, Xinao, Jiang, Jinlan
Format: Article
Language:English
Subjects:
depression
immunomodulation
mechanisms
Pharmacology
review
stem cells
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Summary:Depression is a common affective disorder characterized by persistent low mood, diminished interest or pleasure in normally enjoyable activities, disturbances in sleep patterns, and suicidal ideation. Conventional treatments often yield unsatisfactory results and are associated with several adverse effects. However, emerging literature has highlighted the potential of stem cell (SC) transplantation as a promising avenue for treating depression owing to its favorable anti-inflammatory and neurotrophic properties. This review summarizes the therapeutic effects and underlying mechanisms associated with SC transplantation in depression, offering a conceptual framework for the future application of SCs in the clinical treatment of depression.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1476558