Genetic polymorphism for IFNγ +874T/A in patients with acute toxoplasmosis

A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2012-12, Vol.45 (6), p.757-760
Main Authors: Neves, Elizabeth de Souza, Curi, André Luis Land, Albuquerque, Maira Cavalcanti de, Palhano-Silva, Cassius Schnel, Silva, Laura Berriel da, Bueno, Wendy Fernandes, Amendoeira, Maria Regina Dos Reis, Bonecini-Almeida, Maria da Gloria, Fernandes, Octavio
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Case-Control Studies
Chorioretinitis - genetics
Chorioretinitis - parasitology
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interferon-gama
Interferon-gamma - genetics
Male
Polymorphism, Single Nucleotide - genetics
Retinocoroidite
Severity of Illness Index
Toxoplasmose
Toxoplasmosis - genetics
Toxoplasmosis, Ocular - genetics
TROPICAL MEDICINE
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Summary:A single nucleotide polymorphism (SNP) in the gene encoding gamma interferon influences its production and is associated with severity of infectious diseases. This study aimed to evaluate the association of IFNγ+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis. A case-control study was conducted among 30 patients and 90 controls. Although statistical associations were not confirmed, A-allele was more common among retinochoroiditis cases and prolonged illness, while T-allele was more frequent in severe disease. Despite few cases, the results could indicate a relation between IFNγ+874T/A single nucleotide polymorphism and clinical manifestations of toxoplasmosis.
ISSN:0037-8682
1678-9849
1678-9849
0037-8682
DOI:10.1590/S0037-86822012000600020