Viral labeling of neurons synaptically connected to nucleus accumbens somatostatin interneurons

The nucleus accumbens, a key brain reward region, receives synaptic inputs from a range of forebrain and brainstem regions. Many of these projections have been established using electrophysiology or fluorescent tract tracing. However, more recently developed viral tracing techniques have allowed for...

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Bibliographic Details
Published in:PloS one 2019-03, Vol.14 (3), p.e0213476-e0213476
Main Authors: Ribeiro, Efrain A, Nectow, Alexander R, Pomeranz, Lisa E, Ekstrand, Mats I, Koo, Ja Wook, Nestler, Eric J
Format: Article
Language:English
Subjects:
Animals
Aujeszky's disease
Biology and Life Sciences
Brain
Cocaine
Electrophysiology
Future predictions
Green Fluorescent Proteins - blood
Health aspects
Herpesvirus 1, Suid - metabolism
Immunohistochemistry
Interneurons - cytology
Interneurons - metabolism
Interneurons - virology
Male
Medicine and Health Sciences
Mice
Neurons
Nucleus accumbens
Nucleus Accumbens - cytology
Nucleus Accumbens - metabolism
Nucleus Accumbens - virology
Physical Sciences
Somatostatin
Somatostatin - metabolism
Staining and Labeling
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Summary:The nucleus accumbens, a key brain reward region, receives synaptic inputs from a range of forebrain and brainstem regions. Many of these projections have been established using electrophysiology or fluorescent tract tracing. However, more recently developed viral tracing techniques have allowed for fluorescent labeling of synaptic afferents in a cell type-specific manner. Since the NAc is comprised of multiple cell types, these methods have enabled the delineation of the cell type-specific connectivity of principal medium spiny neurons in the region. The synaptic connectivity of somatostatin interneurons, which account for
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0213476