Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants

Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mo...

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Bibliographic Details
Published in:Microbiome 2017-09, Vol.5 (1), p.113-113, Article 113
Main Authors: Stanislawski, Maggie A, Dabelea, Dana, Wagner, Brandie D, Sontag, Marci K, Lozupone, Catherine A, Eggesbø, Merete
Format: Article
Language:English
Subjects:
Adult
Bacteria - classification
Bacteria - genetics
Bacteria - isolation & purification
Bifidobacterium - classification
Bifidobacterium - genetics
Bifidobacterium - isolation & purification
Biological diversity
Body Mass Index
Child, Preschool
Female
Gastrointestinal Microbiome - genetics
Genes, rRNA
High-Throughput Nucleotide Sequencing
Humans
Infant
Infant, Newborn
Infants
Microbiota (Symbiotic organisms)
Mothers
Obesity
Overweight
Pregnancy
Pregnant women
RNA
RNA, Ribosomal, 16S - genetics
Weight Gain
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Summary:Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mothers at the time of delivery and their infants in early life. In this study, we performed 16S rRNA gene sequencing on gut microbiota samples from 169 women 4 days after delivery and from the 844 samples of their infants at six timepoints during the first 2 years of life. We categorized the women (1) according to pre-pregnancy body mass index into overweight/obese (OW/OB, BMI ≥ 25) or non-overweight/obese (BMI
ISSN:2049-2618
2049-2618
DOI:10.1186/s40168-017-0332-0