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Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants
Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mo...
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| Published in: | Microbiome 2017-09, Vol.5 (1), p.113-113, Article 113 |
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| creator | Stanislawski, Maggie A Dabelea, Dana Wagner, Brandie D Sontag, Marci K Lozupone, Catherine A Eggesbø, Merete |
| description | Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mothers at the time of delivery and their infants in early life. In this study, we performed 16S rRNA gene sequencing on gut microbiota samples from 169 women 4 days after delivery and from the 844 samples of their infants at six timepoints during the first 2 years of life. We categorized the women (1) according to pre-pregnancy body mass index into overweight/obese (OW/OB, BMI ≥ 25) or non-overweight/obese (BMI |
| doi_str_mv | 10.1186/s40168-017-0332-0 |
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Maternal OW/OB was associated with lower maternal alpha diversity. Maternal pre-pregnancy OW/OB and excessive GWG were associated with taxonomic differences in the maternal gut microbiota, including taxa from the highly heritable family Christensenellaceae, the genera Lachnospira, Parabacteroides, Bifidobacterium, and Blautia. These maternal characteristics were not associated with overall differences in the infant gut microbiota over the first 2 years of life. However, the presence of specific OTUs in maternal gut microbiota at the time of delivery did significantly increase the odds of presence in the infant gut at age 4-10 days for many taxa, and these included some lean-associated taxa.
Our results show differences in maternal gut microbiota composition at the time of delivery by pre-pregnancy weight and GWG, but these changes were only associated with limited compositional differences in the early life gut microbiota of their infants. Further work is needed to determine the degree to which these maternal microbiota differences at time of birth with OW/OB and GWG may affect the health of the infant over time and by what mechanism.</description><identifier>ISSN: 2049-2618</identifier><identifier>EISSN: 2049-2618</identifier><identifier>DOI: 10.1186/s40168-017-0332-0</identifier><identifier>PMID: 28870230</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Bacteria - classification ; Bacteria - genetics ; Bacteria - isolation & purification ; Bifidobacterium - classification ; Bifidobacterium - genetics ; Bifidobacterium - isolation & purification ; Biological diversity ; Body Mass Index ; Child, Preschool ; Female ; Gastrointestinal Microbiome - genetics ; Genes, rRNA ; High-Throughput Nucleotide Sequencing ; Humans ; Infant ; Infant, Newborn ; Infants ; Microbiota (Symbiotic organisms) ; Mothers ; Obesity ; Overweight ; Pregnancy ; Pregnant women ; RNA ; RNA, Ribosomal, 16S - genetics ; Weight Gain</subject><ispartof>Microbiome, 2017-09, Vol.5 (1), p.113-113, Article 113</ispartof><rights>COPYRIGHT 2017 BioMed Central Ltd.</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-ddbd29a40004e918f734e715b11c3e2f8a642c0c7fd32797781b035fe0bc7c603</citedby><cites>FETCH-LOGICAL-c566t-ddbd29a40004e918f734e715b11c3e2f8a642c0c7fd32797781b035fe0bc7c603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584478/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584478/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,36990,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28870230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanislawski, Maggie A</creatorcontrib><creatorcontrib>Dabelea, Dana</creatorcontrib><creatorcontrib>Wagner, Brandie D</creatorcontrib><creatorcontrib>Sontag, Marci K</creatorcontrib><creatorcontrib>Lozupone, Catherine A</creatorcontrib><creatorcontrib>Eggesbø, Merete</creatorcontrib><title>Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants</title><title>Microbiome</title><addtitle>Microbiome</addtitle><description>Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mothers at the time of delivery and their infants in early life. In this study, we performed 16S rRNA gene sequencing on gut microbiota samples from 169 women 4 days after delivery and from the 844 samples of their infants at six timepoints during the first 2 years of life. We categorized the women (1) according to pre-pregnancy body mass index into overweight/obese (OW/OB, BMI ≥ 25) or non-overweight/obese (BMI < 25) and (2) into excessive and non-excessive GWG in the subset of mothers of full-term singleton infants (N = 116). We compared alpha diversity and taxonomic composition of the maternal and infant samples by exposure groups. We also compared taxonomic similarity between maternal and infant gut microbiota.
Maternal OW/OB was associated with lower maternal alpha diversity. Maternal pre-pregnancy OW/OB and excessive GWG were associated with taxonomic differences in the maternal gut microbiota, including taxa from the highly heritable family Christensenellaceae, the genera Lachnospira, Parabacteroides, Bifidobacterium, and Blautia. These maternal characteristics were not associated with overall differences in the infant gut microbiota over the first 2 years of life. However, the presence of specific OTUs in maternal gut microbiota at the time of delivery did significantly increase the odds of presence in the infant gut at age 4-10 days for many taxa, and these included some lean-associated taxa.
Our results show differences in maternal gut microbiota composition at the time of delivery by pre-pregnancy weight and GWG, but these changes were only associated with limited compositional differences in the early life gut microbiota of their infants. Further work is needed to determine the degree to which these maternal microbiota differences at time of birth with OW/OB and GWG may affect the health of the infant over time and by what mechanism.</description><subject>Adult</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Bifidobacterium - classification</subject><subject>Bifidobacterium - genetics</subject><subject>Bifidobacterium - isolation & purification</subject><subject>Biological diversity</subject><subject>Body Mass Index</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - genetics</subject><subject>Genes, rRNA</subject><subject>High-Throughput Nucleotide Sequencing</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Mothers</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>RNA</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Weight Gain</subject><issn>2049-2618</issn><issn>2049-2618</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptUl1rHCEUHUpLE7b5AX0pA31pIZPq6Iz6UgihHwuBln48yx3nOmuY1a26afPv63Y3IQvVB-V67uF6zqmql5RcUCr7d4kT2suGUNEQxtqGPKlOW8JV0_ZUPn10P6nOUrohZSnKBZfPq5NWSkFaRk6r4WvEZhNx8uDNXf0b3bTK5_WEKUN2wcN8qNUTOH9egx_rvMJ62uZ67UwMgwsZ6mDrdSj1mO4RLtbOW_A5vaieWZgTnh3ORfXz44cfV5-b6y-flleX143p-j434ziMrQJe5uSoqLSCcRS0Gyg1DFsroeetIUbYkbVCCSHpQFhnkQxGmJ6wRbXc844BbvQmujXEOx3A6X-FECcNMTszo-6tVFxZShgQXhiBdLzrUUkGQuHQF673e67NdljjaNDnCPMR6fGLdys9hVvddZJzIQvBmwNBDL-2RU29dsngPIPHsE2aKtZJ2rGWF-jrPXSCMloRLRRGs4Pry654RpUoBi-qi_-gyh6x-BA8WlfqRw1vjxoKJuOfPME2Jb38_u0YS_fYYmhKEe3DTynRu7Tpfdp0SZvepU3v5H71WKKHjvtssb_lU82_</recordid><startdate>20170904</startdate><enddate>20170904</enddate><creator>Stanislawski, Maggie A</creator><creator>Dabelea, Dana</creator><creator>Wagner, Brandie D</creator><creator>Sontag, Marci K</creator><creator>Lozupone, Catherine A</creator><creator>Eggesbø, Merete</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170904</creationdate><title>Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants</title><author>Stanislawski, Maggie A ; Dabelea, Dana ; Wagner, Brandie D ; Sontag, Marci K ; Lozupone, Catherine A ; Eggesbø, Merete</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-ddbd29a40004e918f734e715b11c3e2f8a642c0c7fd32797781b035fe0bc7c603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Bacteria - classification</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Bifidobacterium - classification</topic><topic>Bifidobacterium - genetics</topic><topic>Bifidobacterium - isolation & purification</topic><topic>Biological diversity</topic><topic>Body Mass Index</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Gastrointestinal Microbiome - genetics</topic><topic>Genes, rRNA</topic><topic>High-Throughput Nucleotide Sequencing</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Microbiota (Symbiotic organisms)</topic><topic>Mothers</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Pregnancy</topic><topic>Pregnant women</topic><topic>RNA</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanislawski, Maggie A</creatorcontrib><creatorcontrib>Dabelea, Dana</creatorcontrib><creatorcontrib>Wagner, Brandie D</creatorcontrib><creatorcontrib>Sontag, Marci K</creatorcontrib><creatorcontrib>Lozupone, Catherine A</creatorcontrib><creatorcontrib>Eggesbø, Merete</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Microbiome</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanislawski, Maggie A</au><au>Dabelea, Dana</au><au>Wagner, Brandie D</au><au>Sontag, Marci K</au><au>Lozupone, Catherine A</au><au>Eggesbø, Merete</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants</atitle><jtitle>Microbiome</jtitle><addtitle>Microbiome</addtitle><date>2017-09-04</date><risdate>2017</risdate><volume>5</volume><issue>1</issue><spage>113</spage><epage>113</epage><pages>113-113</pages><artnum>113</artnum><issn>2049-2618</issn><eissn>2049-2618</eissn><abstract>Recent evidence supports that the maternal gut microbiota impacts the initial infant gut microbiota. Since the gut microbiota may play a causal role in the development of obesity, it is important to understand how pre-pregnancy weight and gestational weight gain (GWG) impact the gut microbiota of mothers at the time of delivery and their infants in early life. In this study, we performed 16S rRNA gene sequencing on gut microbiota samples from 169 women 4 days after delivery and from the 844 samples of their infants at six timepoints during the first 2 years of life. We categorized the women (1) according to pre-pregnancy body mass index into overweight/obese (OW/OB, BMI ≥ 25) or non-overweight/obese (BMI < 25) and (2) into excessive and non-excessive GWG in the subset of mothers of full-term singleton infants (N = 116). We compared alpha diversity and taxonomic composition of the maternal and infant samples by exposure groups. We also compared taxonomic similarity between maternal and infant gut microbiota.
Maternal OW/OB was associated with lower maternal alpha diversity. Maternal pre-pregnancy OW/OB and excessive GWG were associated with taxonomic differences in the maternal gut microbiota, including taxa from the highly heritable family Christensenellaceae, the genera Lachnospira, Parabacteroides, Bifidobacterium, and Blautia. These maternal characteristics were not associated with overall differences in the infant gut microbiota over the first 2 years of life. However, the presence of specific OTUs in maternal gut microbiota at the time of delivery did significantly increase the odds of presence in the infant gut at age 4-10 days for many taxa, and these included some lean-associated taxa.
Our results show differences in maternal gut microbiota composition at the time of delivery by pre-pregnancy weight and GWG, but these changes were only associated with limited compositional differences in the early life gut microbiota of their infants. Further work is needed to determine the degree to which these maternal microbiota differences at time of birth with OW/OB and GWG may affect the health of the infant over time and by what mechanism.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>28870230</pmid><doi>10.1186/s40168-017-0332-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Microbiome, 2017-09, Vol.5 (1), p.113-113, Article 113 |
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| subjects | Adult Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Bifidobacterium - classification Bifidobacterium - genetics Bifidobacterium - isolation & purification Biological diversity Body Mass Index Child, Preschool Female Gastrointestinal Microbiome - genetics Genes, rRNA High-Throughput Nucleotide Sequencing Humans Infant Infant, Newborn Infants Microbiota (Symbiotic organisms) Mothers Obesity Overweight Pregnancy Pregnant women RNA RNA, Ribosomal, 16S - genetics Weight Gain |
| title | Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants |
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