Biological structural study of emerging shaped nanoparticles for the blood flow in diverging tapered stenosed arteries to see their application in drug delivery

The magnetic force effects and differently shaped nano-particles in diverging tapering arteries having stenoses are being studied in current research via blood flow model. There hasn’t been any research done on using metallic nanoparticles of different shapes with water as the base fluid. A radially...

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Bibliographic Details
Published in:Scientific reports 2024-01, Vol.14 (1), p.1475-13, Article 1475
Main Authors: Akbar, Noreen Sher, Habib, M. Bilal, Rafiq, Maimona, Muhammad, Taseer, Alghamdi, Metib
Format: Article
Language:English
Subjects:
631/1647
639/705
639/925
Arteries
Blood flow
Copper
Drug delivery
Humanities and Social Sciences
Impedance
multidisciplinary
Nanoparticles
Science
Science (multidisciplinary)
Shear stress
Stenosis
Veins & arteries
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Summary:The magnetic force effects and differently shaped nano-particles in diverging tapering arteries having stenoses are being studied in current research via blood flow model. There hasn’t been any research done on using metallic nanoparticles of different shapes with water as the base fluid. A radially symmetric but axially non-symmetric stenosis is used to depict the blood flow. Another significant aspect of our research is the study of symmetrical distribution of wall shearing stresses in connection with resistive impedance, as well as the rise of these quantities with the progression of stenosis. Shaping nanoparticles in accordance with the understanding of blood flow in arteries offers numerous possibilities for improving drug delivery, targeted therapies, and diagnostic imaging in the context of cardiovascular and other vascular-related diseases. Exact solutions for different flow quantities namely velocity, temperature, resistance impedance, boundary shear stress, and shearing stress at the stenosis throat, have been assessed. For various parameters of relevance for Cu-water, the graphical results of several types of tapered arteries (i.e. diverging tapering) have been explored.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-51848-4