Biological structural study of emerging shaped nanoparticles for the blood flow in diverging tapered stenosed arteries to see their application in drug delivery

• Published in: Scientific reports 2024-01, Vol.14 (1), p.1475-13, Article 1475
• Main Authors: Akbar, Noreen Sher, Habib, M. Bilal, Rafiq, Maimona, Muhammad, Taseer, Alghamdi, Metib
• Format: Article
• Language: English
• Subjects: 631/1647; 639/705; 639/925; Arteries; Blood flow; Copper; Drug delivery; Humanities and Social Sciences; Impedance; multidisciplinary; Nanoparticles; Science; Science (multidisciplinary); Shear stress; Stenosis; Veins & arteries
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-51848-4

The magnetic force effects and differently shaped nano-particles in diverging tapering arteries having stenoses are being studied in current research via blood flow model. There hasn’t been any research done on using metallic nanoparticles of different shapes with water as the base fluid. A radially symmetric but axially non-symmetric stenosis is used to depict the blood flow. Another significant aspect of our research is the study of symmetrical distribution of wall shearing stresses in connection with resistive impedance, as well as the rise of these quantities with the progression of stenosis. Shaping nanoparticles in accordance with the understanding of blood flow in arteries offers numerous possibilities for improving drug delivery, targeted therapies, and diagnostic imaging in the context of cardiovascular and other vascular-related diseases. Exact solutions for different flow quantities namely velocity, temperature, resistance impedance, boundary shear stress, and shearing stress at the stenosis throat, have been assessed. For various parameters of relevance for Cu-water, the graphical results of several types of tapered arteries (i.e. diverging tapering) have been explored.