The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats

It is well established that diminished reproductive health is one of the notable long-term outcomes of type 2 diabetes mellitus (T2DM), especially among males. Due to the global increasing rate of T2DM and infertility, we aimed to investigate the impact of , inulin, and their combinatory supplementa...

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Published in:Diabetology and metabolic syndrome 2020-06, Vol.12 (1), p.53-53, Article 53
Main Authors: Rahimiyan-Heravan, Marziyeh, Roshangar, Leila, Karimi, Pouran, Sefidgari-Abrasi, Safa, Morshedi, Mohammad, Saghafi-Asl, Maryam, Bavafa-Valenlia, Khadijeh
Format: Article
Language:English
Subjects:
Androgen receptors
Animals
Carbohydrates
Cell number
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Fertility
Food
Health aspects
Hypothalamus
Infertility
Inulin
Kiss1 protein
Kisspeptin
Lactobacillus plantarum
Metabolites
Microbiota
Oxidative stress
Prebiotics
Probiotics
Proteins
Reproductive health
Rodents
Sperm
Spermatogenesis
Streptozocin
Supplements
Testes
Tubules
Type 2 diabetes
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Summary:It is well established that diminished reproductive health is one of the notable long-term outcomes of type 2 diabetes mellitus (T2DM), especially among males. Due to the global increasing rate of T2DM and infertility, we aimed to investigate the impact of , inulin, and their combinatory supplementation on fertility markers as well as testicular kisspeptin and androgen receptor (AR)'s expression in diabetic male rats. Thirty-five Male Wistar rats with Streptozotocin-induced T2DM were supplemented with , inulin, or their combination for 8 weeks. At the end-point, the animals were sacrificed and serum, testicular, and seminal parameters were studied. Administration of and inulin in diabetic male rats improved sperm motility and viability (P 
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-020-00560-0