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The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats
It is well established that diminished reproductive health is one of the notable long-term outcomes of type 2 diabetes mellitus (T2DM), especially among males. Due to the global increasing rate of T2DM and infertility, we aimed to investigate the impact of , inulin, and their combinatory supplementa...
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| Published in: | Diabetology and metabolic syndrome 2020-06, Vol.12 (1), p.53-53, Article 53 |
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| container_title | Diabetology and metabolic syndrome |
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| creator | Rahimiyan-Heravan, Marziyeh Roshangar, Leila Karimi, Pouran Sefidgari-Abrasi, Safa Morshedi, Mohammad Saghafi-Asl, Maryam Bavafa-Valenlia, Khadijeh |
| description | It is well established that diminished reproductive health is one of the notable long-term outcomes of type 2 diabetes mellitus (T2DM), especially among males. Due to the global increasing rate of T2DM and infertility, we aimed to investigate the impact of
, inulin, and their combinatory supplementation on fertility markers as well as testicular kisspeptin and androgen receptor (AR)'s expression in diabetic male rats.
Thirty-five Male Wistar rats with Streptozotocin-induced T2DM were supplemented with
, inulin, or their combination for 8 weeks. At the end-point, the animals were sacrificed and serum, testicular, and seminal parameters were studied.
Administration of
and inulin in diabetic male rats improved sperm motility and viability (P |
| doi_str_mv | 10.1186/s13098-020-00560-0 |
| format | article |
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, inulin, and their combinatory supplementation on fertility markers as well as testicular kisspeptin and androgen receptor (AR)'s expression in diabetic male rats.
Thirty-five Male Wistar rats with Streptozotocin-induced T2DM were supplemented with
, inulin, or their combination for 8 weeks. At the end-point, the animals were sacrificed and serum, testicular, and seminal parameters were studied.
Administration of
and inulin in diabetic male rats improved sperm motility and viability (P < 0.001, both) as well as testicular tissue development via increasing leydig cell number, testicular spermatid count, and diameter of seminiferous tubules (P < 0.001, all). Testicular expression of Kisspeptin was elevated by inulin supplementation (P = 0.01).
administration increased testicular AR expression (P = 0.01). The expression of Kisspeptin showed a remarkable correlation with fertility markers (P < 0.001).
Supplementation with either
, inulin, or their combination can prevent infertility caused by T2DM in male rats via improving testicular kisspeptin and AR expression, leydig cell count, and effectively increasing epididymal sperm motility and viability.</description><identifier>ISSN: 1758-5996</identifier><identifier>EISSN: 1758-5996</identifier><identifier>DOI: 10.1186/s13098-020-00560-0</identifier><identifier>PMID: 32607132</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Androgen receptors ; Animals ; Carbohydrates ; Cell number ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Fertility ; Food ; Health aspects ; Hypothalamus ; Infertility ; Inulin ; Kiss1 protein ; Kisspeptin ; Lactobacillus plantarum ; Metabolites ; Microbiota ; Oxidative stress ; Prebiotics ; Probiotics ; Proteins ; Reproductive health ; Rodents ; Sperm ; Spermatogenesis ; Streptozocin ; Supplements ; Testes ; Tubules ; Type 2 diabetes</subject><ispartof>Diabetology and metabolic syndrome, 2020-06, Vol.12 (1), p.53-53, Article 53</ispartof><rights>The Author(s) 2020.</rights><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5090-e951fce5b5b9c4b66455c9dffefd633eaca466884f4582d9ebfe7b5d42647c353</citedby><cites>FETCH-LOGICAL-c5090-e951fce5b5b9c4b66455c9dffefd633eaca466884f4582d9ebfe7b5d42647c353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318432/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2424737273?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32607132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahimiyan-Heravan, Marziyeh</creatorcontrib><creatorcontrib>Roshangar, Leila</creatorcontrib><creatorcontrib>Karimi, Pouran</creatorcontrib><creatorcontrib>Sefidgari-Abrasi, Safa</creatorcontrib><creatorcontrib>Morshedi, Mohammad</creatorcontrib><creatorcontrib>Saghafi-Asl, Maryam</creatorcontrib><creatorcontrib>Bavafa-Valenlia, Khadijeh</creatorcontrib><title>The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats</title><title>Diabetology and metabolic syndrome</title><addtitle>Diabetol Metab Syndr</addtitle><description>It is well established that diminished reproductive health is one of the notable long-term outcomes of type 2 diabetes mellitus (T2DM), especially among males. Due to the global increasing rate of T2DM and infertility, we aimed to investigate the impact of
, inulin, and their combinatory supplementation on fertility markers as well as testicular kisspeptin and androgen receptor (AR)'s expression in diabetic male rats.
Thirty-five Male Wistar rats with Streptozotocin-induced T2DM were supplemented with
, inulin, or their combination for 8 weeks. At the end-point, the animals were sacrificed and serum, testicular, and seminal parameters were studied.
Administration of
and inulin in diabetic male rats improved sperm motility and viability (P < 0.001, both) as well as testicular tissue development via increasing leydig cell number, testicular spermatid count, and diameter of seminiferous tubules (P < 0.001, all). Testicular expression of Kisspeptin was elevated by inulin supplementation (P = 0.01).
administration increased testicular AR expression (P = 0.01). The expression of Kisspeptin showed a remarkable correlation with fertility markers (P < 0.001).
Supplementation with either
, inulin, or their combination can prevent infertility caused by T2DM in male rats via improving testicular kisspeptin and AR expression, leydig cell count, and effectively increasing epididymal sperm motility and viability.</description><subject>Androgen receptors</subject><subject>Animals</subject><subject>Carbohydrates</subject><subject>Cell number</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Fertility</subject><subject>Food</subject><subject>Health aspects</subject><subject>Hypothalamus</subject><subject>Infertility</subject><subject>Inulin</subject><subject>Kiss1 protein</subject><subject>Kisspeptin</subject><subject>Lactobacillus plantarum</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Oxidative stress</subject><subject>Prebiotics</subject><subject>Probiotics</subject><subject>Proteins</subject><subject>Reproductive health</subject><subject>Rodents</subject><subject>Sperm</subject><subject>Spermatogenesis</subject><subject>Streptozocin</subject><subject>Supplements</subject><subject>Testes</subject><subject>Tubules</subject><subject>Type 2 diabetes</subject><issn>1758-5996</issn><issn>1758-5996</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl1rFDEYhQdRbK3-AS8kIIg3U_OdmRuhFD8KC97U65BJ3uxmzUzWZKbgX_BXm-22tSsyMBPeOefJy-E0zWuCzwnp5IdCGO67FlPcYixkfT9pTokSXSv6Xj59dD5pXpSyxVgqofjz5oRRiRVh9LT5fb0BtEszTHMwEc0byGYHyxwsAu_BzgUlj1bGzmkwNsS4FLSLZppNXkZkJofCtMQwoTShAvezGUolLNFklGGXk1vsHG4AjSb_gFyqB7lgBthfM5oIKJu5vGyeeRMLvLr7njXfP3-6vvzarr59ubq8WLVW4B630AviLYhBDL3lg5RcCNu7uqx3kjEw1nApu457Ljrqehg8qEE4TiVXlgl21lwduC6Zrd7lULf6pZMJ-naQ8lqbXDeLoKXvhZMSPJWOO8oGMIoyJcSe6hmvrI8H1m4ZRnC2xphNPIIe_5nCRq_TjVaMdJzRCnh_B8jp51Jj02MoFmKNGNJSNOWk50RS1Vfp23-k27TkqUZVVZQrpqhif1XrmqsOk0_1XruH6gtJO0wEk_u9z_-jqo-DMdg0gQ91fmR498iwARPnTUmxFiVN5VhID0KbUykZ_EMYBOt9bfWhtrrWVt_WVuNqevM4xgfLfU_ZH6md6eA</recordid><startdate>20200626</startdate><enddate>20200626</enddate><creator>Rahimiyan-Heravan, Marziyeh</creator><creator>Roshangar, Leila</creator><creator>Karimi, Pouran</creator><creator>Sefidgari-Abrasi, Safa</creator><creator>Morshedi, Mohammad</creator><creator>Saghafi-Asl, Maryam</creator><creator>Bavafa-Valenlia, Khadijeh</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20200626</creationdate><title>The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats</title><author>Rahimiyan-Heravan, Marziyeh ; 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Due to the global increasing rate of T2DM and infertility, we aimed to investigate the impact of
, inulin, and their combinatory supplementation on fertility markers as well as testicular kisspeptin and androgen receptor (AR)'s expression in diabetic male rats.
Thirty-five Male Wistar rats with Streptozotocin-induced T2DM were supplemented with
, inulin, or their combination for 8 weeks. At the end-point, the animals were sacrificed and serum, testicular, and seminal parameters were studied.
Administration of
and inulin in diabetic male rats improved sperm motility and viability (P < 0.001, both) as well as testicular tissue development via increasing leydig cell number, testicular spermatid count, and diameter of seminiferous tubules (P < 0.001, all). Testicular expression of Kisspeptin was elevated by inulin supplementation (P = 0.01).
administration increased testicular AR expression (P = 0.01). The expression of Kisspeptin showed a remarkable correlation with fertility markers (P < 0.001).
Supplementation with either
, inulin, or their combination can prevent infertility caused by T2DM in male rats via improving testicular kisspeptin and AR expression, leydig cell count, and effectively increasing epididymal sperm motility and viability.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>32607132</pmid><doi>10.1186/s13098-020-00560-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; Publicly Available Content (ProQuest) |
| subjects | Androgen receptors Animals Carbohydrates Cell number Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Fertility Food Health aspects Hypothalamus Infertility Inulin Kiss1 protein Kisspeptin Lactobacillus plantarum Metabolites Microbiota Oxidative stress Prebiotics Probiotics Proteins Reproductive health Rodents Sperm Spermatogenesis Streptozocin Supplements Testes Tubules Type 2 diabetes |
| title | The potential therapeutic effects of Lactobacillus plantarum and inulin on serum and testicular reproductive markers in diabetic male rats |
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