Epigenetic Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease in which immune disorders lead to autoreactive immune responses and cause inflammation and tissue damage. Genetic and environmental factors have been shown to trigger SLE. Recent evidence has also demonstrated that epigenetic fac...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-01, Vol.25 (2), p.1019
Main Authors: Araki, Yasuto, Mimura, Toshihide
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoimmune Diseases
Autoimmunity
B cells
Cell division
Chemokines
Chromatin
Disease
Disease susceptibility
DNA methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Epigenomics
Genes
Genetic aspects
Genetic transcription
histone modification
Humans
Immune response
Immune system
Immunology
Inflammation
Interferon
Lupus
Lupus Erythematosus, Systemic - genetics
Lymphocytes
microRNA
MicroRNAs
Mitochondrial DNA
Neutrophils
Pathogenesis
Proteins
Systemic lupus erythematosus
Tumor necrosis factor-TNF
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Summary:Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease in which immune disorders lead to autoreactive immune responses and cause inflammation and tissue damage. Genetic and environmental factors have been shown to trigger SLE. Recent evidence has also demonstrated that epigenetic factors contribute to the pathogenesis of SLE. Epigenetic mechanisms play an important role in modulating the chromatin structure and regulating gene transcription. Dysregulated epigenetic changes can alter gene expression and impair cellular functions in immune cells, resulting in autoreactive immune responses. Therefore, elucidating the dysregulated epigenetic mechanisms in the immune system is crucial for understanding the pathogenesis of SLE. In this paper, we review the important roles of epigenetic disorders in the pathogenesis of SLE.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25021019