Two New Stilbenoids from the Aerial Parts of Arundina graminifolia (Orchidaceae)

Two new phenanthrene derivatives, a phenanthrenequinone named arundiquinone ( ) and a 9,10-dihydrophenanthrene named arundigramin ( ) together with a known lignin dimer ( ) and seven known stilbenoids ( - ) were isolated from the aerial parts of the Asian orchid . The structures of the isolated comp...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-11, Vol.21 (11), p.1430-1430
Main Authors: Auberon, Florence, Olatunji, Opeyemi Joshua, Krisa, Stéphanie, Antheaume, Cyril, Herbette, Gaëtan, Bonté, Frédéric, Mérillon, Jean-Michel, Lobstein, Annelise
Format: Article
Language:English
Subjects:
Amyloid beta-Peptides - toxicity
Animals
arundigramin
Arundina graminifolia
arundiquinone
Cell Survival - drug effects
Chromatography
Cytoprotection - drug effects
Cytotoxicity
Life Sciences
Metabolites
Orchidaceae
Orchidaceae - chemistry
PC12 Cells
Pharmacy
phenanthrene derivatives
Phytochemicals
Plant Components, Aerial - chemistry
Rats
Spectrum analysis
Stilbenes - chemistry
Stilbenes - isolation & purification
Stilbenes - pharmacology
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Summary:Two new phenanthrene derivatives, a phenanthrenequinone named arundiquinone ( ) and a 9,10-dihydrophenanthrene named arundigramin ( ) together with a known lignin dimer ( ) and seven known stilbenoids ( - ) were isolated from the aerial parts of the Asian orchid . The structures of the isolated compounds were elucidated by spectroscopic methods, including extensive 1D, 2D NMR (heteronuclear single quantum coherence (HSQC), heteronuclear multiple-bond correlation spectroscopy (HMBC), and HR-ESI-MS techniques, as well as comparison with respective literature reports. The cytoprotective activity of the isolated compounds were evaluated for their ability to reduce beta amyloid induced toxicity on undifferentiated PC12 cells. Compound showed moderate cytoprotective activity at 0.5 µmol/L (71% of cell viability) while the other compounds showed no significant activity at the highest concentration tested.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21111430