Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats

• Published in: Clinics (São Paulo, Brazil) Brazil), 2012-07, Vol.67 (7), p.815-820
• Main Authors: Mostarda, Cristiano, Moraes-Silva, Ivana Cinthya, Salemi, Vera Maria Cury, Machi, Jacqueline Freire, Rodrigues, Bruno, De Angelis, Kátia, de Moura Azevedo Farah, Vera, Irigoyen, Maria Claudia
• Format: Article
• Language: English
• Subjects: Animals; Basic Research; Cardiac hypertrophy; Diastole - physiology; Diastolic function; Disease Models, Animal; Exercise Training; Fructose - adverse effects; Insulin resistance; Male; MEDICINE, GENERAL & INTERNAL; Metabolic Syndrome; Metabolic Syndrome - complications; Metabolic Syndrome - physiopathology; Physical Conditioning, Animal - physiology; Rats; Rats, Wistar; Sweetening Agents - adverse effects; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - prevention & control
• ISSN: 1807-5932; 1980-5322; 1980-5322
• DOI: 10.6061/clinics/2012(07)18

High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p