Antimicrobial Resistance Challenged with Platinum(II) and Palladium(II) Complexes Containing 1,10-Phenanthroline and 5-Amino-1,3,4-Thiadiazole-2(3H)-Thione in Campylobacter jejuni

This work describes the synthesis and characterization of two metal complexes of the type [M(L1)2(phen)], where M = Pt2+ (complex I) or Pd2+ (complex II), L1 = 5-amino-1,3,4-thiadiazole-2(3H)-thiolate and phen = 1,10-phenanthroline. The in vitro antibacterial activity of these complexes was investig...

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Published in:Antibiotics (Basel) 2022-11, Vol.11 (11), p.1645
Main Authors: Lacerda, Meiry Leandra de, Rossi, Daise Aparecida, Lourenzatto, Eduarda Cristina Alves, Takeuchi, Micaela Guidotti, Souza, Wesley Almeida, Silva, Raphael Tristão Cruvinel, Julio, Luma Gonçalves, Guerra, Wendell, Melo, Roberta Torres de
Format: Article
Language:English
Subjects:
Antibacterial activity
Antibiotics
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
bacterial resistance
Bioavailability
Campylobacter
Campylobacter jejuni
Ciprofloxacin
Coordination compounds
Drug resistance
Epidemiology
Erythromycin
Infections
Ligands
Metal complexes
Metal ions
metal-based drugs
NMR
Nuclear magnetic resonance
Palladium
Pathogens
Platinum
platinum(II) complexes
Sulfur
synergism
Synergistic effect
Thiadiazoles
Zoonoses
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Summary:This work describes the synthesis and characterization of two metal complexes of the type [M(L1)2(phen)], where M = Pt2+ (complex I) or Pd2+ (complex II), L1 = 5-amino-1,3,4-thiadiazole-2(3H)-thiolate and phen = 1,10-phenanthroline. The in vitro antibacterial activity of these complexes was investigated in isolation and synergistically with ciprofloxacin (CIP) and erythromycin (ERY) in three strains of Campylobacter jejuni (MIC = 32 mg/L for CIP and ERY), selected from a bank of 235 strains representative of three poultry exporting states of the country (A, B and C), previously analyzed for epidemiology and resistance to CIP and ERY. A total of 53/235 (22.55%) strains showed co-resistance to CIP and ERY. Isolated resistance to CIP was higher than to ERY. Epidemiological analysis showed that resistance to CIP was more evident in state B (p < 0.0001), as well as a higher susceptibility to ERY in state C (p = 0.0028). Co-resistance was expressive in state A and in the spring and fall seasons. The evaluation of I alone and in synergy with CIP and ERY found values up to 0.25 mg/L not significant for ERY. Complex II did not show an antimicrobial effect on the three strains of tested C. jejuni. The effect provided by complex I represents a promising alternative for control of resistant strains of C. jejuni.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11111645