Loading…
Effects of Helicobacter pylori Infection on the Oral Microbiota of Reflux Esophagitis Patients
The human oral microbiota plays a vital role in maintaining metabolic homeostasis. To explore the relationship between Helicobacter pylori ( Hp ) and reflux esophagitis, we collected 86 saliva samples from reflux esophagitis patients (RE group) and 106 saliva samples from healthy people (C group) fo...
Saved in:
Published in: | Frontiers in cellular and infection microbiology 2021-09, Vol.11, p.732613-732613 |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | The human oral microbiota plays a vital role in maintaining metabolic homeostasis. To explore the relationship between
Helicobacter pylori
(
Hp
) and reflux esophagitis, we collected 86 saliva samples from reflux esophagitis patients (RE group) and 106 saliva samples from healthy people (C group) for a high-throughput sequencing comparison. No difference in alpha diversity was detected between the RE and the C groups, but beta diversity of the RE group was higher than the C group. Bacteroidetes was more abundant in the RE group, whereas Firmicutes was more abundant in the C group. The linear discriminant analysis effect size analysis demonstrated that the biomarkers of the RE group were
Prevotella
,
Veillonella
,
Leptotrichia
, and
Actinomyces
, and the biomarkers of the C group were
Lautropia
,
Gemella
,
Rothia
, and
Streptococcus
. The oral microbial network structure of the C group was more complex than that of the RE group. Second, to explore the effect of
Hp
on the oral microbiota of RE patients, we performed the
14
C-urea breath test on 45 of the 86 RE patients. We compared the oral microbiota of 33
Hp
-infected reflux esophagitis patients (REHpp group) and 12 non-Hp-infected reflux esophagitis patients (REHpn group). No difference in alpha diversity was observed between the REHpn and REHpp groups, and beta diversity of the REHpp group was significantly lower than that of the REHpn group. The biomarkers in the REHpp group were
Veillonella
,
Haemophilus
,
Selenomonas
,
Megasphaera
,
Oribacterium
,
Butyrivibrio
, and
Campylobacter
; and the biomarker in the REHpn group was
Stomatobaculum
.
Megasphaera
was positively correlated with
Veillonella
in the microbial network of the REHpp group. The main finding of this study is that RE disturbs the human oral microbiota, such as increased beta diversity.
Hp
infection may inhibit this disorderly trend. |
---|---|
ISSN: | 2235-2988 2235-2988 |
DOI: | 10.3389/fcimb.2021.732613 |