In Vivo Analysis of the Biocompatibility and Macrophage Response of a Non-Resorbable PTFE Membrane for Guided Bone Regeneration

The use of non-resorbable polytetrafluoroethylene (PTFE) membranes is indicated for the treatment of large, non-self-containing bone defects, or multi-walled defects in the case of vertical augmentations. However, less is known about the molecular basis of the foreign body response to PTFE membranes...

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Bibliographic Details
Published in:International journal of molecular sciences 2018-09, Vol.19 (10), p.2952
Main Authors: Korzinskas, Tadas, Jung, Ole, Smeets, Ralf, Stojanovic, Sanja, Najman, Stevo, Glenske, Kristina, Hahn, Michael, Wenisch, Sabine, Schnettler, Reinhard, Barbeck, Mike
Format: Article
Language:English
Subjects:
Animals
biocompatibility
Biocompatible Materials - adverse effects
Biocompatible Materials - chemistry
Bone Regeneration
Cells, Cultured
collagen membrane
Female
Foreign-Body Reaction - etiology
Guided Tissue Regeneration - methods
inflammation
macrophage
Macrophages - drug effects
Membranes, Artificial
Mice
Mice, Inbred BALB C
Polytetrafluoroethylene - adverse effects
PTFE membrane
tissue reaction
Tissue Scaffolds - adverse effects
Tissue Scaffolds - chemistry
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Summary:The use of non-resorbable polytetrafluoroethylene (PTFE) membranes is indicated for the treatment of large, non-self-containing bone defects, or multi-walled defects in the case of vertical augmentations. However, less is known about the molecular basis of the foreign body response to PTFE membranes. In the present study, the inflammatory tissue responses to a novel high-density PTFE (dPTFE) barrier membrane have preclinically been evaluated using the subcutaneous implantation model in BALB/c mice by means of histopathological and histomorphometrical analysis methods and immunohistochemical detection of M1- and M2-macrophages. A collagen membrane was used as the control material. The results of the present study demonstrate that the tissue response to the dPTFE membrane involves inflammatory macrophages, but comparable cell numbers were also detected in the implant beds of the control collagen membrane, which is known to be biocompatible. Although these data indicate that the analyzed dPTFE membrane is not fully bioinert, but its biocompatibility is comparable to collagen-based membranes. Based on its optimal biocompatibility, the novel dPTFE barrier membrane may optimally support bone healing within the context of guided bone regeneration (GBR).
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms19102952