Ubiquitin specific peptidase 3: an emerging deubiquitinase that regulates physiology and diseases

Proteins are the keystone for the execution of various life activities, and the maintenance of protein normalization is crucial for organisms. Ubiquitination, as a post-transcriptional modification, is widely present in organisms, and it relies on the sophisticated ubiquitin-proteasome (UPS) system...

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Bibliographic Details
Published in:Cell death discovery 2024-05, Vol.10 (1), p.243-243, Article 243
Main Authors: Wang, Yizhu, Shi, Yanlong, Niu, Kaiyi, Yang, Rui, Lv, Qingpeng, Zhang, Wenning, Feng, Kun, Zhang, Yewei
Format: Article
Language:English
Subjects:
631/337/458/582
631/67/1857
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cell Biology
Cell cycle
Cell Cycle Analysis
Chromatin
DNA damage
Gastric cancer
Genomes
Glioblastoma
Homeostasis
Immune system
Inflammation
Innate immunity
Life Sciences
Life span
Neuroblastoma
Post-transcription
Proteasomes
Proteins
Review
Review Article
Stem Cells
Ubiquitin
Ubiquitination
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Summary:Proteins are the keystone for the execution of various life activities, and the maintenance of protein normalization is crucial for organisms. Ubiquitination, as a post-transcriptional modification, is widely present in organisms, and it relies on the sophisticated ubiquitin-proteasome (UPS) system that controls protein quality and modulates protein lifespan. Deubiquitinases (DUBs) counteract ubiquitination and are essential for the maintenance of homeostasis. Ubiquitin specific peptidase 3 (USP3) is a member of the DUBs that has received increasing attention in recent years. USP3 is a novel chromatin modifier that tightly regulates the DNA damage response (DDR) and maintains genome integrity. Meanwhile, USP3 acts as a key regulator of inflammatory vesicles and sustains the normal operation of the innate immune system. In addition, USP3 is aberrantly expressed in a wide range of cancers, such as gastric cancer, glioblastoma and neuroblastoma, implicating that USP3 could be an effective target for targeted therapies. In this review, we retrace all the current researches of USP3, describe the structure of USP3, elucidate its functions in DNA damage, immune and inflammatory responses and the cell cycle, and summarize the important role of USP3 in multiple cancers and diseases.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-024-02010-6