Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus

Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimate...

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Bibliographic Details
Published in:Mediators of Inflammation 2010-01, Vol.2010 (2010), p.1062-1076
Main Authors: van den Oever, Inge A. M., Raterman, Hennie G., Nurmohamed, Mike T., Simsek, Suat
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - physiology
Complications and side effects
Development and progression
Diabetes Complications - pathology
Diabetes Complications - physiopathology
Diabetes Mellitus - pathology
Diabetes Mellitus - physiopathology
Endothelium
Endothelium, Vascular - pathology
Endothelium, Vascular - physiopathology
Health aspects
Humans
Inflammation
Inflammation - pathology
Inflammation - physiopathology
Review
Signal Transduction - immunology
Type 2 diabetes
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Summary:Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.
ISSN:0962-9351
1466-1861
DOI:10.1155/2010/792393