Human Plasma Xanthine Oxidoreductase Activity in Cardiovascular Disease: Evidence from a Population-Based Study

Xanthine oxidoreductase (XOR) and its products contribute to the development of chronic inflammation and oxidative stress. Excessive XOR activity is believed to promote inflammatory responses and atherosclerotic plaque formation, which are major cardiovascular risk factors. The mechanisms of XOR act...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicines 2023-03, Vol.11 (3), p.754
Main Authors: Kotozaki, Yuka, Satoh, Mamoru, Nasu, Takahito, Tanno, Kozo, Tanaka, Fumitaka, Sasaki, Makoto
Format: Article
Language:English
Subjects:
Arteriosclerosis
atherosclerosis
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Chromatography
Dehydrogenases
Endothelium
Enzymes
Hypoxia
Inflammation
Liver
Measurement techniques
Milk
Molybdenum
Nitrates
Nitric oxide
Oils & fats
Oxidation
Oxidative stress
Oxidoreductases
Permeability
Physiological aspects
Physiology
Plasma
plasma xanthine oxidoreductase
Population studies
Population-based studies
Proteins
Reactive oxygen species
reactive oxygen species production
renal function
Review
Risk factors
Sulfur
Uric acid
Xanthine oxidoreductase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Xanthine oxidoreductase (XOR) and its products contribute to the development of chronic inflammation and oxidative stress. Excessive XOR activity is believed to promote inflammatory responses and atherosclerotic plaque formation, which are major cardiovascular risk factors. The mechanisms of XOR activity in the development and progression of cardiovascular disease (CVD), coupled with the complexity of the relationship between XOR activity and the biological effects of uric acid; reactive oxygen species; and nitric oxide, which are the major products of XOR activity, have long been debated, but have not yet been clearly elucidated. Recently, a system for measuring highly sensitive XOR activity in human plasma was established, and there has been progress in the research on the mechanisms of XOR activity. In addition, there are accumulating findings about the relationship between XOR activity and CVD. In this narrative review, we summarize existing knowledge regarding plasma XOR activity and its relationship with CVD and discuss future perspectives.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11030754