Role of Histone Post-Translational Modifications in Inflammatory Diseases

Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer's disease, psoriasis, asthma, chronic lung diseases, inflammatory bowel disea...

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Published in:Frontiers in immunology 2022-02, Vol.13, p.852272-852272
Main Authors: Lin, Yingying, Qiu, Ting, Wei, Guifeng, Que, Yueyue, Wang, Wenxin, Kong, Yichao, Xie, Tian, Chen, Xiabin
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 2
DNA Methylation
epigenetic
histone modifications
Histones - metabolism
Humans
immune
Immunology
inflammation
Inflammation - metabolism
inflammatory diseases
Protein Processing, Post-Translational
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Summary:Inflammation is a defensive reaction for external stimuli to the human body and generally accompanied by immune responses, which is associated with multiple diseases such as atherosclerosis, type 2 diabetes, Alzheimer's disease, psoriasis, asthma, chronic lung diseases, inflammatory bowel disease, and multiple virus-associated diseases. Epigenetic mechanisms have been demonstrated to play a key role in the regulation of inflammation. Common epigenetic regulations are DNA methylation, histone modifications, and non-coding RNA expression; among these, histone modifications embrace various post-modifications including acetylation, methylation, phosphorylation, ubiquitination, and ADP ribosylation. This review focuses on the significant role of histone modifications in the progression of inflammatory diseases, providing the potential target for clinical therapy of inflammation-associated diseases.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.852272