Effect of hyperbaric oxygen therapy in rats with subtotal splenectomy preserving the inferior pole Efeito da oxigenoterapia hiperbárica em ratos submetidos à esplenectomia subtotal com preservação do polo inferior

PURPOSE: To evaluate the effect of hyperbaric oxygen therapy on the survival and weight of rats submitted to subtotal splenectomy and on the viability and growth of the inferior pole. METHODS: Forty Wistar rats underwent subtotal splenectomy with preservation of the inferior pole and distributed int...

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Bibliographic Details
Published in:Acta cirúrgica brasileira 2011-06, Vol.26 (3), p.156-164
Main Authors: Marcela Souza Lima Paulo, Isabel Cristina Andreatta Lemos Paulo, Tarcizo Afonso Nunes, Alcino Lázaro da Silva, Luiz Cálice Cintra, Danilo Nagib Salomão Paulo
Format: Article
Language:English
Subjects:
Animal Experimentation
Esplenectomia
Experimentação Animal
Hyperbaric Oxygenation
Oxigenação Hiperbárica
Splenectomy
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Summary:PURPOSE: To evaluate the effect of hyperbaric oxygen therapy on the survival and weight of rats submitted to subtotal splenectomy and on the viability and growth of the inferior pole. METHODS: Forty Wistar rats underwent subtotal splenectomy with preservation of the inferior pole and distributed into two groups: Group A (n=20) - not treated with hyperbaric oxygen, Group B (n=20) - treated with hyperbaric oxygen. These groups were divided into two subgroups of 10 animals each, according to the time of euthanasia, 15th and 45th days. The survival and weight of the animals were recorded. The inferior pole was measured, weighed and morphologically analyzed. RESULTS: All animals survived. The weight of the animals increased in all subgroups, but decreased on the 10th day in the subgroups treated with hyperbaric oxygen (p
ISSN:0102-8650
1678-2674
DOI:10.1590/S0102-86502011000300002