Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET...

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Published in:Alzheimer's & dementia : diagnosis, assessment & disease monitoring assessment & disease monitoring, 2018, Vol.10 (1), p.669-677
Main Authors: Joseph-Mathurin, Nelly, Su, Yi, Blazey, Tyler M., Jasielec, Mateusz, Vlassenko, Andrei, Friedrichsen, Karl, Gordon, Brian A., Hornbeck, Russ C., Cash, Lisa, Ances, Beau M., Veale, Thomas, Cash, David M., Brickman, Adam M., Buckles, Virginia, Cairns, Nigel J., Cruchaga, Carlos, Goate, Alison, Jack, Clifford R., Karch, Celeste, Klunk, William, Koeppe, Robert A., Marcus, Daniel S., Mayeux, Richard, McDade, Eric, Noble, James M., Ringman, John, Saykin, Andrew J., Thompson, Paul M., Xiong, Chengjie, Morris, John C., Bateman, Randall J., Benzinger, Tammie L.S.
Format: Article
Language:English
Subjects:
Alzheimer's disease
Biomarkers
Brain research
Dementia
Demographics
FDG
Glucose
Magnetic resonance imaging
Metabolism
Mutation
Neuroimaging
Neuronal injury
Older people
Perfusion
PiB
Radiation
Regions
Standard deviation
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Summary:18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.
ISSN:2352-8729
2352-8729
DOI:10.1016/j.dadm.2018.08.012