Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been impl...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-06, Vol.24 (13), p.10479
Main Authors: Anastasi, Emanuela, Farina, Antonella, Granato, Teresa, Colaiacovo, Flavia, Pucci, Beatrice, Tartaglione, Sara, Angeloni, Antonio
Format: Article
Language:English
Subjects:
Algorithms
Angiogenesis
Biomarkers
Biomarkers, Tumor - metabolism
CA-125 Antigen
Cancer
Carcinogenesis
Cell Transformation, Neoplastic - genetics
Development and progression
Diagnosis
Endometriosis
Epididymis
Female
HE4
Health risk assessment
Humans
Immune response
Immunoassay
Medical prognosis
Mutation
oncogenesis
Oncology, Experimental
Ovarian cancer
Ovarian Neoplasms - diagnosis
Prognosis
Proteins
Proteins - metabolism
Review
target therapy
Tumorigenesis
Tumors
Ultrasonic imaging
Womens health
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Summary:Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241310479