The Impact of Origanum vulgare Supplementation on Human Asthenozoospermic Sperm Parameter Quality

Male infertility is a complex multifactorial disease and a real health problem; 50% of infertile men have identifiable causes detectable by fundamental sperm analysis. Numerous research studies have shown the possibility of treating abnormal semen samples with some drugs before artificial inseminati...

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Bibliographic Details
Published in:TheScientificWorld 2023, Vol.2023, p.8093795-6
Main Authors: Zarhouti, Ahlam, Mbaye, Moudou M., Addoum, Boutaina, Louanjli, Noureddine, El Khalfi, Bouchra, Soukri, Abdelaziz
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Artificial insemination
Biomarkers
Catalase
Deoxyribonucleic acid
DNA
Effectiveness
Endangered & extinct species
Enzymes
Essential oils
Eucalyptus
Extinction
In vitro fertilization
Infertility
Laboratories
Lipid peroxidation
Lipids
Metabolism
Motility
Oils & fats
Oregano
Origanum vulgare
Oxidation
Parameters
Peroxidation
Physiological aspects
Physiological effects
Physiology
Proteins
Semen
Sperm
Spermatozoa
Superoxide
Superoxide dismutase
Supplements
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Summary:Male infertility is a complex multifactorial disease and a real health problem; 50% of infertile men have identifiable causes detectable by fundamental sperm analysis. Numerous research studies have shown the possibility of treating abnormal semen samples with some drugs before artificial insemination, yet evidence of the drug’s effectiveness remains minimal. In our previous work, we tested the effectiveness of some essential oils, such as eucalyptus (Eucalyptus globulus Labill.), oregano (Origanum vulgare L.), and sage (Salvia officinalis L.) on sperm parameters. The essential oil of oregano showed the best ameliorative effect. In present, we examined the effect of the essential oil of O. vulgare on the physiological parameters and the specific activity of certain antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), lipid peroxidation rate (MDA), and GAPDH and antioxidant and metabolic biomarkers, characterizing the quality of human sperm. The results showed that in vitro supplementation of oregano significantly improves the mobility and antioxidant activities, without harmful effects on the integrity of the sperm’s DNA, and that the selected concentration of oregano EO is nontoxic and may be considered a therapeutic alternative to heal sperm motility problems in asthenozoospermic patients.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2023/8093795