A prospective, randomized, open-label, placebo-controlled comparative study of Bacillus coagulans GBI-30,6086 with digestive enzymes in improving indigestion in geriatric population

Introduction: Digestive symptoms are common affecting more than 60% of the elderly people. Digestive enzyme deficiency and dysbiosis in the gastric fluid microbiota are the major contributors in the pathophysiology of indigestion. Therefore, therapeutic strategy targeting the gastric microbiota and...

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Bibliographic Details
Published in:Journal of family medicine and primary care 2020-02, Vol.9 (2), p.1108-1112
Main Authors: Kumar, V, Sudha, Kulur, Bennur, Shilpa, Dhanasekar, Karukkupalayam
Format: Article
Language:English
Subjects:
bacillus coagulans
Comparative analysis
Comparative literature
digestive enzymes
Digestive symptoms
Elderly
Elderly patients
Enzymes
geriatrics
Indigestion
Labels
Medical research
Microbiota (Symbiotic organisms)
Original
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Summary:Introduction: Digestive symptoms are common affecting more than 60% of the elderly people. Digestive enzyme deficiency and dysbiosis in the gastric fluid microbiota are the major contributors in the pathophysiology of indigestion. Therefore, therapeutic strategy targeting the gastric microbiota and digestive enzymes has the potential to treat indigestion. This study was conducted to evaluate the efficacy and tolerability of probiotic Bacillus coagulans GBI30,6086 along with digestive enzymes in improving indigestion in geriatric population. Methods: An open-labelled, randomized, prospective study was conducted in geriatric patients with complaints of indigestion. The study group (n = 25) received 5 ml of reconstituted probiotic syrup containing Bacillus coagulans GBI-30, 6086, and digestive enzymes daily and the control group (n = 25) received 5 ml of placebo syrup twice daily for 5 days and followed-up after 7 days. Results: Reduction in Modified Glasgow dyspepsia severity score from baseline to follow up was statistically significant in the study group when compared to the control group (P < 0.0001). Improvement in indigestion, abdominal pain, and flatulence was also greater in the study group compared to the control group. Conclusion: Bacillus coagulans along with digestive enzymes are effective in treating indigestion in geriatric patients. It is well tolerated and safe to be used in geriatric patients without any major adverse effects.
ISSN:2249-4863
2278-7135
DOI:10.4103/jfmpc.jfmpc_922_19