Comparative Study of Cognitive Function Between Treatment-Resistant Depressive Patients and First-Episode Depressive Patients

Despite reports of cognitive dysfunction during the acute phase of depression, there is a lack of studies in patients with treatment-resistant depression (TRD). The aim of this study was to investigate the cognitive function profile of TRD and compare cognitive dysfunction between subjects with TRD...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2019-12, Vol.15, p.3411-3417
Main Authors: Rao, Dongping, Xu, Guiyun, Lu, Zenghong, Liang, Huiwei, Lin, Kangguang, Tang, Muni
Format: Article
Language:English
Subjects:
Alcohol
Anxiety
Between-subjects design
Bipolar disorder
Brain damage
Brain research
Care and treatment
Cognitive ability
Cognitive disorders
cognitive dysfunction
Comparative analysis
Comparative literature
Comparative studies
Depression (Mood disorder)
Disabilities
Drug abuse
Executive function
first-episode depression
Independent sample
Intelligence
Medical research
Mental depression
Mental disorders
Original Research
Psychosis
Studies
treatment-resistant depression
Vortioxetine
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Summary:Despite reports of cognitive dysfunction during the acute phase of depression, there is a lack of studies in patients with treatment-resistant depression (TRD). The aim of this study was to investigate the cognitive function profile of TRD and compare cognitive dysfunction between subjects with TRD and first-episode depression. The study included 31 patients with TRD and 53 with first-episode depression. Cognitive function was assessed by a series of neuropsychological tools such as the verbal fluency test, Modified Wisconsin Card Sorting Test (M-WCST), Tower of Hanoi test, Chinese-revision of the Wechsler Adult Intelligence Scale (WAIS-RC), and Trail Making Test A and B. There were no significant demographic differences between the TRD, first-episode depression, and normal control groups (gender, age, years of education). The full-scale, verbal, and performance intelligence quotients measured with the WAIS-RC were also not significantly different (p>0.05). The normal group scores were all significantly better than TRD and first-episode depression, and the TRD group performed significantly worse than subjects with first-episode depression on Trail Making Test B, two WCST subscales, and the profile score of the Tower of Hanoi test (all p
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S226405