Global Evolutionary History and Dynamics of Dengue Viruses Inferred from Whole Genome Sequences

Dengue is an arboviral disease caused by dengue virus (DENV), leading to approximately 25,000 deaths/year and with over 40% of the world's population at risk. Increased international travel and trade, poorly regulated urban expansion, and warming global temperatures have expanded the geographic...

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Bibliographic Details
Published in:Viruses 2022-03, Vol.14 (4), p.703
Main Authors: Stica, Caleb J, Barrero, Roberto A, Murray, Rachael Z, Devine, Gregor J, Phillips, Matthew J, Frentiu, Francesca D
Format: Article
Language:English
Subjects:
Aedes
Amino acids
arbovirus
Biological control
Datasets
Dengue
Dengue fever
Dengue Virus
Disease control
Env gene
Epidemics
evolution
Evolution, Molecular
Evolutionary genetics
Genome, Viral
Genomes
Genotype
Genotypes
Humans
mosquito
Mosquitoes
Mutation
Negative selection
Phylogenetics
Phylogeny
Positive selection
RNA polymerase
Vaccines
Viruses
Wolbachia
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Summary:Dengue is an arboviral disease caused by dengue virus (DENV), leading to approximately 25,000 deaths/year and with over 40% of the world's population at risk. Increased international travel and trade, poorly regulated urban expansion, and warming global temperatures have expanded the geographic range and incidence of the virus in recent decades. This study used phylogenetic and selection pressure analyses to investigate trends in DENV evolution, using whole genome coding sequences from publicly available databases alongside newly sequenced isolates collected between 1963-1997 from Southeast Asia and the Pacific. Results revealed very similar phylogenetic relationships when using the envelope gene and the whole genome coding sequences. Although DENV evolution is predominantly driven by negative selection, a number of amino acid sites undergoing positive selection were found across the genome, with the majority located in the envelope and NS5 genes. Some genotypes appear to be diversifying faster than others within each serotype. The results from this research improve our understanding of DENV evolution, with implications for disease control efforts such as -based biocontrol and vaccine design.
ISSN:1999-4915
1999-4915
DOI:10.3390/v14040703