Turner Syndrome: Searching for Better Outcomes

• Published in: Clinics (São Paulo, Brazil) Brazil), 2008-04, Vol.63 (2), p.173-178
• Main Authors: Ramos, Adauto Versiani, Silva, Ivani Novato, Goulart, Eugênio Marcos Andrade
• Format: Article
• Language: English
• Subjects: Adult height; Anabolic Agents - therapeutic use; Body Height - drug effects; Child; Clinical Sciences; Cohort Studies; Estrogen Replacement Therapy; Female; Follow-Up Studies; Growth; Growth Disorders - drug therapy; Growth Disorders - etiology; Growth hormone; Growth Hormone - administration & dosage; Growth Hormone - therapeutic use; Growth velocity; Humans; MEDICINE, GENERAL & INTERNAL; Oxandrolone - administration & dosage; Oxandrolone - therapeutic use; Regression Analysis; Time Factors; Treatment Outcome; Turner syndrome; Turner Syndrome - complications
• ISSN: 1807-5932; 1980-5322; 1980-5322
• DOI: 10.1590/S1807-59322008000200004

To assess the results of growth hormone on the growth of girls with Turner Syndrome and identify relevant parameters to improve outcomes. Growth velocity and final height were studied in a historical cohort of 41 girls, regularly followed up for hormone distribution at three referral centers. The influence of oxandrolone and of estrogens on the final height was analyzed. The girls (initial chronological age=8.9±3.4years; initial bone age=7.0±3.1years) used 0.19 mg/kg/week of growth hormone for 4.0 ± 2.0 years. In the first year, growth velocity increased by 71.5% in 41 girls and 103.4% in those who reached final height (11 girls). The whole group had a gain in the height SDS of 0.8 ± 0.7 (p