Advances in Conductive Hydrogel for Spinal Cord Injury Repair and Regeneration

Spinal cord injury (SCI) treatment represents a major challenge in clinical practice. In recent years, the rapid development of neural tissue engineering technology has provided a new therapeutic approach for spinal cord injury repair. Implanting functionalized electroconductive hydrogels (ECH) in t...

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Bibliographic Details
Published in:International journal of nanomedicine 2023-01, Vol.18, p.7305-7333
Main Authors: Qin, Cheng, Qi, Zhiping, Pan, Su, Xia, Peng, Kong, Weijian, Sun, Bin, Du, Haorui, Zhang, Renfeng, Zhu, Longchuan, Zhou, Dinghai, Yang, Xiaoyu
Format: Article
Language:English
Subjects:
Biocompatible Materials - therapeutic use
Biological products
conductive biomaterials
electrical signal
electrical stimulation
Health aspects
Humans
Hydrogels - therapeutic use
Nerve Regeneration - physiology
neural tissue engineering
Neurons
Neurophysiology
Review
Spinal Cord
Spinal Cord Injuries - drug therapy
spinal cord injury microenvironment
Spinal Cord Regeneration
Tissue Engineering
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Summary:Spinal cord injury (SCI) treatment represents a major challenge in clinical practice. In recent years, the rapid development of neural tissue engineering technology has provided a new therapeutic approach for spinal cord injury repair. Implanting functionalized electroconductive hydrogels (ECH) in the injury area has been shown to promote axonal regeneration and facilitate the generation of neuronal circuits by reshaping the microenvironment of SCI. ECH not only facilitate intercellular electrical signaling but, when combined with electrical stimulation, enable the transmission of electrical signals to electroactive tissue and activate bioelectric signaling pathways, thereby promoting neural tissue repair. Therefore, the implantation of ECH into damaged tissues can effectively restore physiological functions related to electrical conduction. This article focuses on the dynamic pathophysiological changes in the SCI microenvironment and discusses the mechanisms of electrical stimulation/signal in the process of SCI repair. By examining electrical activity during nerve repair, we provide insights into the mechanisms behind electrical stimulation and signaling during SCI repair. We classify conductive biomaterials, and offer an overview of the current applications and research progress of conductive hydrogels in spinal cord repair and regeneration, aiming to provide a reference for future explorations and developments in spinal cord regeneration strategies.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S436111