An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices

L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family contain significant amounts of L-dopa. Due to i...

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Bibliographic Details
Published in:Separations 2022-08, Vol.9 (8), p.224
Main Authors: Tesoro, Carmen, Lelario, Filomena, Ciriello, Rosanna, Bianco, Giuliana, Di Capua, Angela, Acquavia, Maria Assunta
Format: Article
Language:English
Subjects:
Amino acids
Aqueous solutions
Beans
Bioavailability
Biosynthesis
Catecholamines
chromatographic methods
Dopa
Dopamine
Electrophoresis
Enzymes
extraction
Hallucinations
High performance liquid chromatography
Homogenization
Isoflavones
Legumes
levodopa
Mass spectrometry
Mathematical analysis
Metabolism
Metabolites
Methods
Mimosaceae
Parkinson's disease
Phenols
Physical properties
plant matrices
review
Seeds
Spectral methods
Spectrometry
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Summary:L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family contain significant amounts of L-dopa. Due to its low stability, the unambiguous determination of L-dopa in plant matrices requires appropriate technologies. Several analytical methods have been developed for the determination of L-dopa in different plants. The most used for quantification of L-dopa are mainly based on capillary electrophoresis or chromatographic methods, i.e., high-performance liquid chromatography (HPLC), coupled to ultraviolet-visible or mass spectrometric detection. HPLC is most often used. This paper aims to give information on the latest developments in the chemical study of L-dopa, emphasizing the extraction, separation and characterization of this compound by chromatographic, electrochemical and spectral techniques. This study can help select the best possible strategy for determining L-dopa in plant matrices using advanced analytical methods.
ISSN:2297-8739
2297-8739
DOI:10.3390/separations9080224