Cancer before and after the start of hemodialysis and association with mortality - an Eastern-European multicenter study

• Published in: Renal failure 2023-12, Vol.45 (1), p.2232046-2232046
• Main Authors: Gadalean, Florica, Ciorcan, Mircea, Apostol, Adrian, Schiller, Oana, Ivan, Viviana, Petrica, Ligia, Bob, Flaviu, Milas, Oana, Simulescu, Anca, Glavan, Mihaela, Parv, Florina, Timar, Bogdan, Timar, Romulus, Schiller, Adalbert
• Format: Article
• Language: English
• Subjects: Cancer; East European multicenter study; end-stage kidney disease; End-stage renal disease; Gastrointestinal tract; Hemodialysis; hemodialysis patients; Humans; Kidney diseases; Kidney Failure, Chronic - therapy; Mortality; Neoplasms - epidemiology; Nephritis; Nephritis, Interstitial; Renal Dialysis - adverse effects; Retrospective Studies; risk; Risk factors
• ISSN: 0886-022X; 1525-6049
• DOI: 10.1080/0886022X.2023.2232046

East-European data on cancer in patients undergoing hemodialysis (HD) are scarce. This study aimed to assess the pattern of cancer and related mortality in patients with end-stage kidney disease (ESKD) undergoing HD. Retrospectively analyzing data from 7 HD centers, this study examined 1377 incident HD patients divided into three groups: no-cancers (NoC), cancers that occurred prior to HD initiation (CPI) and de novo cancer developed after HD initiation (DNC). Mortality risk and survival trends within groups were analyzed using Cox regression and Kaplan-Meier methods. In the cohort, 89.46% of the patients had no cancer (NoC group), 3.63% had cancer before (CPI group), and 6.89% had cancer after HD initiation (DNC group). The mean time from HD initiation to DNC diagnosis was 1 [2.75] years. Older age was associated with a higher risk of developing DNC (p