The Anti-Inflammatory Properties of Mesenchymal Stem Cells in Epilepsy: Possible Treatments and Future Perspectives

Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases. In addition to the reparative functions of MSCs, g...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-12, Vol.21 (24), p.9683
Main Authors: Salari, Valentina, Mengoni, Francesca, Del Gallo, Federico, Bertini, Giuseppe, Fabene, Paolo Francesco
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - therapeutic use
Antigens
Brain research
Cell cycle
Cell Differentiation
Cell therapy
Cell- and Tissue-Based Therapy - methods
Chemokines
Convulsions & seizures
Cytokines
Epilepsy
Epilepsy - immunology
Epilepsy - pathology
Epilepsy - therapy
epileptic seizure
epileptogenesis
Fibroblasts
Gene expression
Health services
Humans
Immune system
Immunology
Immunomodulation
Inflammation
Inflammation - immunology
Inflammation - pathology
Inflammation - therapy
Inflammatory bowel disease
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
Mesenchymal Stem Cells - cytology
Neurological diseases
neurological disorders
Physiology
Prophylaxis
Review
Stem cells
Tumor necrosis factor-TNF
Umbilical cord
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Summary:Mesenchymal stem cells (MSCs) are multipotent adult cells with self-renewing capacities. MSCs display specific properties, such as the ability to repair damaged tissues, resulting in optimal candidates for cell therapy against degenerative diseases. In addition to the reparative functions of MSCs, growing evidence shows that these cells have potent immunomodulatory and anti-inflammatory properties. Therefore, MSCs are potential tools for treating inflammation-related neurological diseases, including epilepsy. In this regard, over the last decades, epilepsy has no longer been considered a purely neuronal pathology, since inflammatory events underlying the genesis of epilepsy have been demonstrated. This review assessed current knowledge on the use of MSCs in the treatment of epilepsy. Mostly, attention will be focused on the anti-inflammatory and immunological skills of MSCs. Understanding the mechanisms by which MSCs might modulate the severity of the disease will contribute to the development of new potential alternatives for both prophylaxis and treatment against epilepsy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21249683