Serum uric acid and cardiovascular mortality in chronic kidney disease: a meta-analysis

Conflicting results have been reported from studies evaluating serum uric acid (SUA) levels as an independent risk factor for cardiovascular mortality in patients with chronic kidney disease (CKD). We systematically searched MEDLINE, Web of Science, and bibliographies of retrieved articles to identi...

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Bibliographic Details
Published in:BMC nephrology 2019-01, Vol.20 (1), p.18-18, Article 18
Main Authors: Luo, Qimei, Xia, Xi, Li, Bin, Lin, Zhenchuan, Yu, Xueqing, Huang, Fengxian
Format: Article
Language:English
Subjects:
Biological markers
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - mortality
Cardiovascular mortality
Care and treatment
Chronic kidney disease
Clinical trials
Cohort Studies
Comorbidity
Complications and side effects
Confidence Intervals
Health aspects
Health risk assessment
Humans
Identification and classification
Kidney diseases
Meta-analysis
Mortality
Nephrology
Proportional Hazards Models
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - therapy
Risk Factors
Serum uric acid
Studies
Systematic review
Uric acid
Uric Acid - blood
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Summary:Conflicting results have been reported from studies evaluating serum uric acid (SUA) levels as an independent risk factor for cardiovascular mortality in patients with chronic kidney disease (CKD). We systematically searched MEDLINE, Web of Science, and bibliographies of retrieved articles to identify studies reporting on the association between SUA levels and cardiovascular mortality in patients with CKD. Random-effects models were used to calculate the pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI). We included 11 studies with an overall sample of 27,081 patients with CKD in this meta-analysis. By meta-analysis, restricted to 7 studies (n = 11,050), patients with the highest SUA were associated with an increased risk of cardiovascular mortality (HR 1.47, 95% CI 1.11-1.96) compared with patients with the lowest SUA. There was no indication of publication bias or significant heterogeneity (I  = 40.4%; P = 0.109). Meta-analysis of 10 studies (n = 26,660) indicated that every 1 mg/dl increase in SUA levels increased a 12% risk in cardiovascular mortality (HR 1.12, 95% CI 1.02-1.24), with significant heterogeneity (I  = 79.2%, P 
ISSN:1471-2369
1471-2369
DOI:10.1186/s12882-018-1143-7